| 原发性宫颈腺癌组织中hr-HPV DNA检测和P16蛋白的表达 |
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| 引用本文： | 熊艳,熊永炎,徐智高. 原发性宫颈腺癌组织中hr-HPV DNA检测和P16蛋白的表达[J]. 武汉大学学报(医学版), 2011, 32(3): 365-368,封2 |
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| 作者姓名： | 熊艳 熊永炎 徐智高 |
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| 作者单位： | 1. 武汉大学中南医院妇瘤科/湖北省肿瘤生物学行为重点实验室/湖北省肿瘤医学临床研究中心,湖北武汉,430071
2. 武汉大学中南医院病理科/湖北省肿瘤生物学行为重点实验室/湖北省肿瘤医学临床研究中心,湖北武汉,430071 |
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| 摘 要： | 目的:观察宫颈腺癌和正常宫颈腺体组织中高危人乳头瘤病毒(hr-HPV)(16/18)检出率和P16蛋白表达的差异,探讨hr-HPV(16/18)感染与P16蛋白表达在宫颈腺癌发生中的可能关系.方法:采用原位杂交及免疫组织化学EliVisionTM plus染色技术,分别对33例宫颈腺癌和25例正常宫颈腺体组织中hr-H...
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| 关 键 词： | 高危人乳头瘤病毒 P16 原位杂交 免疫组织化学 宫颈腺癌 |
Detections of High-Risk Human Papillomavirus DNA and Immunohisto-Chemical Expression of P16 in Primary Endocervical Adenocarcinomas |
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| XIONG Yan,XIONG Yongyan,XU Zhigao. Detections of High-Risk Human Papillomavirus DNA and Immunohisto-Chemical Expression of P16 in Primary Endocervical Adenocarcinomas[J]. Medical Journal of Wuhan University, 2011, 32(3): 365-368,封2 |
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| Authors: | XIONG Yan XIONG Yongyan XU Zhigao |
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| Affiliation: | XIONG Yan1,XIONG Yongyan2,XU Zhigao2 1Dept.of Gynecological Oncology,Hubei Key Laboratory of Tumor Biological Behaviors,&Hubei Cancer Clinical Study Center,2 Dept.of Pathology,Zhongnan Hospital of Wuhan University,Wuhan 430071,China |
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| Abstract: | Objective: To observe the differences in detection of high-risk human papillomavirus(hr-HPV)(16/18) DNA and P16 protein expression between endocervical adenocarcinoma(ECA) and normal endocervical glands,and to explore the relationship between hr-HPV infection and P16 protein expression in primary ECA.Methods: Thirty-three cases of ECA and 25 normal endocervical glands tissues were collected and detected for hr-HPV(16/18) DNA using in situ hybridization assay and for P16 protein expression using immunohistoc... |
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| Keywords: | hr-HPV DNA P16 In Situ Hybridization Immunohistochemistry Endocervical Adenocarcinoma |
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