硬膜外与静脉术后镇痛对上腹部手术患者血浆免疫球蛋白的影响

目的:观察硬膜外镇痛和静脉镇痛对上腹部手术后患者血浆免疫球蛋白浓度的影响.方法:选择上腹部手术患者90例,随机分为3组,每组30例.第1组患者给予哌替啶50 mg肌肉注射.第Ⅱ组为术后应用一次性镇痛泵持续静脉镇痛.第Ⅲ组为术后应用一次性镇痛泵持续硬膜外镇痛.对血浆免疫球蛋白和视觉模拟评分(VAS)进行比较分析.结果:与...

Effect of Epidural Analgesia and Intravenous Analgesia on Plasma Immunoglobulins Levels for Postoperative Analgesia of Upper Abdominal Surgery

Objective: To observe the effect of epidural analgesia and intravenous analgesia on the plasma immunoglobulins concentration for postoperative analgesia of upper abdominal surgery.Methods: Ninety patients after upper abdominal surgery were randomly and equally divided into group Ⅰ(intramuscular injection of pethidine 50 mg),group Ⅱ(continuous intravenous analgesia) and group Ⅲ(continuous epidural analgesia).Immunoglobulins and visual analogue score(VAS) of postoperative analgesia were measured.Results: Immunoglobulins at all time points significantly reduced in group Ⅰ as compared with that respectively before operation.Immunoglobulins of group Ⅱ reduced significantly during operation and on the first day after operation.Immunoglobulins on the third day recovered to the level of pre-operation.Immunoglobulins of group Ⅱ on the third postoperative day increased significantly as compared with that of group Ⅰ.The effect of analgesia was the best in group Ⅲ,and the effect was better in groupⅡ than that in group Ⅰ.Conclusion: Epidural analgesia is better than intravenous analgesia and temporary analgesia for postoperative analgesia,and epidural analgesia can attenuate the immune suppression effects induced by surgical stress.