| 腺苷预处理对缺血再灌注心肌血红素加氧酶-1的影响 |
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| 引用本文： | 何祥虎,王焱林,王成夭,饶艳,柯剑娟. 腺苷预处理对缺血再灌注心肌血红素加氧酶-1的影响[J]. 武汉大学学报(医学版), 2011, 32(3): 281-283,封2 |
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| 作者姓名： | 何祥虎 王焱林 王成夭 饶艳 柯剑娟 |
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| 作者单位： | 武汉大学中南医院麻醉科,湖北武汉,430071 |
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| 基金项目： | 国家自然科学基金资助项目(编号:30872426) |
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| 摘 要： | 目的:观察腺苷预处理对心肌缺血再灌注损伤的影响,探讨血红素加氧酶-1(HO-1)在其中的作用.方法:雄性SD大鼠18只,体重(250±16)g,随机分为3组,每组6只:①对照组(C组),②缺血再灌注组(IR组),③腺苷预处理+缺血再灌注组(AP组).采用结扎/放松左冠状动脉前降支建立心肌缺血再灌注损伤模型.再灌注结束后...
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| 关 键 词： | 预处理 腺苷 心肌再灌注损伤 血红素加氧酶-1 |
Effects of Adenosine Preconditioning on Heme Oxygenase-1 Expression in Myocardial Ischemia/Reperfusion Injury in Rats |
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| HE Xianghu,WANG Yanlin,WANG Chengyao,RAO Yan,KE Jianjuan. Effects of Adenosine Preconditioning on Heme Oxygenase-1 Expression in Myocardial Ischemia/Reperfusion Injury in Rats[J]. Medical Journal of Wuhan University, 2011, 32(3): 281-283,封2 |
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| Authors: | HE Xianghu WANG Yanlin WANG Chengyao RAO Yan KE Jianjuan |
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| Affiliation: | HE Xianghu,WANG Yanlin,WANG Chengyao,RAO Yan,KE Jianjuan Dept.of Anesthesiology,Zhongnan Hospital of Wuhan University,Wuhan 430071,China |
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| Abstract: | Objective: To investigate the role of heme oxygenase-1(HO-1) in adenosine preconditioning against myocardial ischemia/reperfusion injury in rats.Methods: Eighteen male SD rats were randomly divided into three groups(n=6): control group(group C),ischemia/reperfusion group(group IR),and adenosine preconditioning+ischemia/reperfusion group(group AP).The left anterior descending coronary artery was ligated for 30 min and loosed for 120 min to establish the model of myocardial ischemia/reperfusion injury.At the ... |
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| Keywords: | Preconditioning Adenosine Myocardial Reperfusion Injury Heme Oxygenase |
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