| 慢性脑低灌注大鼠海马Nrf2的表达及当归注射液的抗氧化作用 |
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| 引用本文： | 杨英,章军建,刘晖,张磊,徐艳.慢性脑低灌注大鼠海马Nrf2的表达及当归注射液的抗氧化作用[J].武汉大学学报(医学版),2011,32(1):16-19. |
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| 作者姓名： | 杨英 章军建 刘晖 张磊 徐艳 |
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| 作者单位： | 武汉大学中南医院神经科,湖北,武汉,430071 |
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| 基金项目： | 湖北省自然科学基金重点项目(编号:2007ABD004) |
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| 摘 要： | 目的:研究慢性脑低灌注大鼠海马核因子E2相关因子2(Nrf2)的表达.以及当归注射液对其的作用.方法:双侧颈总动脉结扎(2VO)术式制备慢性脑低灌注大鼠模型共25只,随机分为生理盐水组(9只)、当归治疗组(9只)和假手术对照组(7只).自2VO术后5周起,当归治疗组给予当归注射液腹腔注射,另两组给予牛理盐水,共持续4周...
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| 关 键 词： | 慢性脑低灌注 大鼠模型 核因子E2相关因子2 当归 |
Expression of Nrf2 in Hippocampus in Rat Model of Chronic Cerebral Hypoperfusion and the Protection of Angelica Injection Against Oxidative Stress |
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| YANG Ying,ZHANG Junjian,LIU Hui,ZHANG Lei,XU Yan.Expression of Nrf2 in Hippocampus in Rat Model of Chronic Cerebral Hypoperfusion and the Protection of Angelica Injection Against Oxidative Stress[J].Medical Journal of Wuhan University,2011,32(1):16-19. |
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| Authors: | YANG Ying ZHANG Junjian LIU Hui ZHANG Lei XU Yan |
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| Institution: | YANG Ying,ZHANG Junjian,LIU Hui,ZHANG Lei,XU Yan Dept. of Neurology,Zhongnan Hospital of Wuhan University,Wuhan 430071,China |
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| Abstract: | Objective: To examine the effect of chronic cerebral hypoperfusion (CCH) on the expression of nuclear factor E2-related factor 2(Nrf2) in rat hippocampus and the role of Angelica injection in oxidative stress caused by chronic cerebral hypoperfusion (CCH). Methods: Rats models of CCH were established by bilateral common carotid artery occlusion (2VO). Rats were randomly divided into 2VO+angelica injection group, 2VO+saline group, and sham+saline group. Four weeks after the operation, each group was administ... |
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| Keywords: | Chronic Cerebral Hypoperfusion Rat Model Nuclear Factor E2-Related Factor Angelica |
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