根除幽门螺杆菌对降低部队官兵消化性溃疡复发率的价值

目的探讨根除幽门螺杆菌(Hp)与降低消化性溃疡(PU)复发的相关性,确定适合于部队的根除HP治疗方案。方法对照组为957例未接受规范抗Hp治疗的军人PU患者;治疗组为1371例Hp阳性的军人PU患者,采用奥美拉唑联合呋喃唑酮和甲硝唑方案治疗;对部分未达根除者,76例采用补救方案Ⅰ(奥美拉唑联合阿莫西林和呋喃唑酮)、65例采用补救方案Ⅱ(奥美拉唑联合左氧氟沙星和阿莫西林)治疗。观察两组的溃疡复发率及各治疗方案的Hp根除率。结果 治疗组溃疡愈合率较对照组明显提高(P<0.01),溃疡复发率明显降低(P<0.01)。一线方案及补救方案Ⅰ、Ⅱ之Hp根除率分别为84.68%(1161/1371)、86.84%(66/76)、89.23%(58/65),总Hp根除率93.73%(1285/1371)。结论根除Hp可明显降低PU患者的复发率,以奥美拉唑联合呋喃唑酮和甲硝唑的治疗方案及补救治疗方案,疗效可靠,副作用小,价格低廉,适宜在部队中推广应用。

The study on the reduction of the peptic ulcer's recurrence rate in soldiers after H.pylori eradication

Objective To investigate the correlation between the eradication of the Hp and reduction of the PU recurrence.To determine the suitable therapy of the eradication of Hp and reduce the PU relapse in troops.Methods Army PU patients were divided into trial group（n=1371） and control group（n=957）.Patients in the trial group received anti-Hp therapy which include the first-line therapy（omeprazole,furazolidone,metronidazole for 10 days） and remedial therapy（scheme one： omeprazole,amoxicillin,furazolidone and scheme two： omeprazole,levofloxacin,amoxicillin for 7 days）.Patients in control group didnt receive regular anti-Hp therapy.Results The eradication rate of the first line therapy and remedial therapy scheme one and two were 84.68%,86.84%,and 89.23%,respectively.The eradication rate of all patients in the trial group was 93.7%.Compared with the control group,the ulcer cure rate improved obviously（P0.01）,the recurrence rate decreased significantly（P0.01）.Conclusion The eradication of Hp obviously decreases the rate of relapse.Omeprazole plus furazolidone and metronidazole as the first-line therapy and remedial therapy schemes in PU patients associated with Hp infection.It is effective,compliable,little side effects,cheap,appropriate for army extended using.