Impact of carbapenem administration on systemic endotoxemia in patients with severe sepsis and Gram-negative bacteremia |
| |
Authors: | Giamarellos-Bourboulis E J Mega A Pavleas I Archontoulis N Rigas K Vernikos P Giamarellou H Thomopoulos G |
| |
Affiliation: | 4th Department of Internal Medicine, University of Athens, Medical School, Greece. giamarel@ath.forthnet.gr |
| |
Abstract: | In order to investigate the effect of carbapenems on systemic endotoxemia, 20 patients with severe sepsis due to ventilator-associated pneumonia and Gram-negative bacteremia were enrolled; 10 (group A) were administered 1 g t.i.d. of imipenem/cilastatin and 10 (group B) 2 g t.i.d. of meropenem. Blood was sampled at 0 time and after 1, 2, 4, 6, 12, 24, 36, 48, 60, 72, 84 and 96 hours for detection of endotoxins (LPS), interleukin-6 (IL-6), C-reactive protein (CRP) and drug levels. LPS were determined by the QCL-1000 LAL assay, IL-6 by an enzymeimmunoassay, CRP by nephelometry and carbapenem levels by a microbiological assay. We did not find that carbapenems had any effect on the kinetics of LPS and CRP; IL-6 of group A was lower than group B at 72 and 84 hours. No correlation was observed between drug levels of any carbapenem and LPS, IL-6 or CRP. It is concluded that in septic patients with Gram-negative bacteremia administration of either imipenem or meropenem did not affect systemic endotoxemia. The above data support the safe administration of both carbapenems in patients with severe sepsis. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|