中国儿童青少年血脂异常流行现状Meta分析

目的 通过Meta分析了解中国儿童青少年血脂异常患病情况.方法 系统检索1974-2014年中国全文数据总库(CNKI)、万方数据库、中国生物医学文献数据库(CBM)中有关中国儿童血脂异常调查的横断面研究中文文献,检索1946-2014年PubMed数据库中研究现场为中国的外文文献.通过STROBE声明进行文献质量评价,利用Stata 11.0软件估计血脂异常的Meta合并患病率,并对三间分布及时间变化趋势执行亚组分析,采用敏感性分析评价文献质量和不同诊断标准对结果的影响.结果 共纳入24篇文献,总样本量为129 426人,中国儿童青少年合并血脂异常总患病率为25.3％(95％CI:12.7％～37.8％).高TC、高LDL-C、高TG、低HDL-C、高脂血症等血脂异常患病率分别为4.1％(95％a:3.4％～4.9％)、5.3％(95％CI:3.9％～6.7％)、8.5％(95％CI:6.3％ ～ 10.7％)、6.8％(95％CI:3.7％～9.9％)、4.8％(95％CI:0.6％～9.1％).男童高TG患病率(5.6％)高于女童(3.4％),高TC、高LDL-C、低HDL-C、高脂血症及血脂异常总患病率男童均低于女童,差异均有统计学意义(P＜0.05).7～18岁儿童青少年血脂异常总患病率(31.6％)高于2～6岁儿童(9.0％),差异有统计学意义(P＜0.05).高TG、高TC及低HDL-C患病率在不同年龄段、地区、时期差异均无统计学意义.结论 中国儿童青少年血脂异常患病率较高,应适时进行血脂筛查,及早发现异常并实施干预.

Prevalence of dyslipidemia in Chinese children and adolescents:a Meta-analysis

Objective To quantify the prevalence of dyslipidemia among children and adolescents in China. Methods Chinese Biomedical Database(CBM), Wanfang Databases, China National Knowledge Infrastructrue (CNKI) and PubMed were comprehensively searched. Original reports were selected if data on prevalence estimates of dyslipdemia among children and adolescents in China, was provided under cross-sectional epidemiological studies. Quality of the literature was evaluated through the STROBE statement. The prevalence through Meta was estimated using the Strata 11.0 software. Subgroup analysis was undertaken on gender, age, regions and secular trends issues. Sensitivity analysis was performed to evaluate the impact of quality or standard of diagnosis. Results A total of 24 papers were included in this Meta-analysis, with the whole sample size as 129 426. The overall pooled-prevalence of total dsylipidemia was estimated at 25.3%(95%CI:12.7%-37.8%). Prevalence rates of high TC, LDL-C, TG, low HDL-C and hyperlipemia were 4.1%(95%CI:3.4%-4.9%), 5.3%(95%CI:3.9%-6.7%), 8.5%(95%CI:6.3%-10.7%), 6.8%(95%CI:3.7%-9.9%), 4.8%(95%CI:0.6%-9.1%), respectively. Girls (3.4%) had lower prevalence of high TG than boys(5.6%), but having higher prevalence of other different types dyslipidemia. Children aged 7-18 years had higher overall prevalence of dyslipidemia(31.6%)when compared to children aged 2-6 years(9.0%). There were no statistically significant differences for subgroups of age, region and period regarding the prevalence rates of high TG, TC and low HDL-C (P >0.05). Conclusion Prevalence of dyslipidemia was high and with increasing trend among children and adolescents in China. Early screening and prevention programs on abnormal serum lipids should be emphasized and promoted.