2型糖尿病患者血糖控制对炎性因子的影响

目的研究2型糖尿病患者炎性因子与血糖控制质量的关系。方法选择临床确诊的2型糖尿病患者160例．其中男性84例，女性76例；年龄42～73岁．平均年龄63．50岁。根据血糖控制程度分为2组：血糖控制良好组（92例）和血糖控制不良组（68例）。同时选择100例健康人为对照组，其中男性55例，女性45例；年龄45～75岁，平均年龄62．80岁。所有参与者的细胞因子——白细胞介素6（IL-6）、肿瘤坏死因子α（TNF-α）、白细胞介素1β（IL-1β）、白细胞介素8（IL-8）浓度应用液体芯片方法检测。结果糖尿病组IL-6、TNF-α、IL-8均显著高于对照组（P〈0．01），且血糖控制不良组IL-6、TNF-α、IL-8亦显著高于血糖控制良好组（P〈0．01）。但IL-1β浓度在对照组与糖尿病组间差异无统计学意义．且与血糖控制程度无关。结论糖尿病患者的细胞因子处于低级别炎症状态．且血糖控制影响炎症水平。

Effect of glycose control in type 2-diabetes patients on inflammatory factors

Objective To investigate the levels of inflammation in type 2-diabetes patients and their relationship with the quality of blood glucose control. Methods A total of 160 type 2-diabetes patients were enrolled, included 84 males and 76 females, who were aged 42 - 73 years old with a mean age of 63.50. Accorded to the levels of glyeosylated hemoglobin（HbAlc）, the patients were divided into 2 groups： well-controlled group（n = 92） and poorly-controlled group（n = 68）. One hundred healthy individuals were taken as control group（55 males and 45 females, aged 45 - 75 years old with a mean age of 62.80）. The serum concentrations of interleukin-6 （IL-6）, tumor necrosis factor-alph a（TNF-α）, interleukin-1β （IL-1β） and interleukin-8（IL-8） in all participants were measured simultaneously by multiplexed Luminex assay. Results There was significant difference in serum levels of IL-6, TNF-α and IL-8 between the patient and control group（all P 〈 0.01）. Moreover, the levels of IL-6, TNF-α and IL-8 of well-controlled group were higher than that of poorly-controlled group （P 〈 0.01）. There was no significant difference in levels of IL-1β between patients and controls. Conclusion It is demonstrated that the cytokine of patients with type 2-diabetes is in a state of low-level inflammation. The change in the serum levels of IL-6, TNF-α and IL-8 is closely associated with the quality of glucose control.