| 凝血酶在脑出血中的作用机制研究进展 |
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| 引用本文： | 丁非凡,王朝燕,代大伟,代亚美.凝血酶在脑出血中的作用机制研究进展[J].中国临床神经科学,2011,19(5):544-550. |
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| 作者姓名： | 丁非凡 王朝燕 代大伟 代亚美 |
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| 作者单位： | 哈尔滨医科大学附属第一医院神经内科,150001 |
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| 基金项目： | 黑龙江省青年科学基金，哈医大一院科研基金 |
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| 摘 要： | 凝血酶是一种丝氨酸蛋白酶,其主要作用是参与机体的凝血、抗凝、血栓形成和纤溶等过程。早先的研究显示在脑出血中凝血酶可以引起血脑屏障的破坏、促进脑水肿的形成,导致神经元死亡,但是新近研究显示凝血酶除了上述作用外,还有促进神经再生、血管再生及脑组织重塑等作用。
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| 关 键 词： | 凝血酶 脑出血 病理生理机制 |
The Advances in Mechanism of Thrombin in the Intracerebral Hemorrhage |
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| DING Fei-Fan,WANG Zhao-Yan,DAI Da-Wei,DAI Ya-Mei.The Advances in Mechanism of Thrombin in the Intracerebral Hemorrhage[J].Chinese Journal of Clinical Neurosciences,2011,19(5):544-550. |
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| Authors: | DING Fei-Fan WANG Zhao-Yan DAI Da-Wei DAI Ya-Mei |
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| Institution: | DING Fei-Fan,WANG Zhao-Yan,DAI Da-Wei,DAI Ya-Mei Department of Neurology,the First Hospital Affiliated to Harbin Medical University,Harbin 150001 China |
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| Abstract: | Thrombin is a serine proteinase which affects our body's blood clotting,anticoagulation,thrombosis and fibrinolysis.Previous studies have showed that thrombin induces blood brain barrier leakage,brain edema,and neuronal death after intracerebral hemorrhage(ICH).However,recent researches have shown that thrombin may facilitate neurogenesis,angiogenesis,plasticity after ICH. |
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| Keywords: | thrombin intracerebral hemorrhage pathophysiology |
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