| 加味逍遥丸对CYP2C19酶活性的影响 |
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| 引用本文： | 赵钢涛,杨凡,许茜,丁媛媛,郑绯,许景峰.加味逍遥丸对CYP2C19酶活性的影响[J].中国临床药理学与治疗学,2011,16(4):407-411. |
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| 作者姓名： | 赵钢涛 杨凡 许茜 丁媛媛 郑绯 许景峰 |
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| 作者单位： | 1. 北京军区总医院药理科,北京,100700
2. 中国人民解放军第302医院药学部,北京,100024 |
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| 摘 要： | 目的:探讨加味逍遥丸对CYP2C19活性的影响,为临床指导联合用药提供依据。方法:将20名受试者按照CYP2C19*2基因型进行分类,野生型纯合子(WW)及突变型纯合子(MM)各10名。以奥美拉唑作为CYP2C19的探针药,研究服用加味逍遥丸对人体内代谢酶CYP2C19活性的影响。采用pyrosequencing测序法对CYP2C19进行基因分型,采用HPLC-MS/MS法测定探针药及其代谢产物的血药浓度。结果:连续服用14 d加味逍遥丸。以AUC0-12为指标,评价CYP2C19代谢酶的活性。受试者用药前CYP2C19代谢酶活性为5.7±1.6,服用加味逍遥丸后CYP2C19代谢酶活性为6.0±1.7。用药后代谢酶的活性升高,用药前后比较采用配对t检验,差异没有统计学意义。结论:服用加味逍遥丸对CYP2C19代谢酶活性没有明显影响。
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| 关 键 词： | 加味逍遥丸 CYP2C19 焦磷酸测序 |
Effect of Modified Xiaoyao pill on the activity of CYP2C19 |
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| ZHAO Gang-tao,YANG Fan,Xu Qian,DING Yuan-yuan,Zheng Fei,XU Jing-feng.Effect of Modified Xiaoyao pill on the activity of CYP2C19[J].Chinese Journal of Clinical Pharmacology and Therapeutics,2011,16(4):407-411. |
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| Authors: | ZHAO Gang-tao YANG Fan Xu Qian DING Yuan-yuan Zheng Fei XU Jing-feng |
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| Institution: | ZHAO Gang-tao1,YANG Fan1,Xu Qian1,DING Yuan-yuan1,Zheng Fei2,XU Jing-feng1 1Department of Pharmacology,General Hospital of Beijing Military Command,Beijing 100700,China,2Department of Pharmacy,NO.302 Hospital of PLA,Beijing 100024 |
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| Abstract: | AIM: To investigate the effect of Modified Xiaoyao pill on CYP2C19,and provide foundation for clinical drug using. METHODS: Twenty volunteers were divided into two groups according to CYP2C19*2 gene type,ten for WW gene type and ten for MM gene type.Omeprazole used as probe drug of CYP2C19,the effect of Modified Xiaoyao pill on the activity of CYP2C19 were investigated.Genetic classification was fulfilled by pyrosequencing method,and the blood concentration of probe drug and its metabolic product were deter... |
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| Keywords: | Modified Xiaoyao pill CYP2C19 Pyrosequencing |
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