骨质疏松高危老年人群骨生化代谢与骨质疏松的相关性分析

目的 探讨骨质疏松高危老年人群骨生化代谢与骨质疏松的关系。方法 从社区65岁以上人群健康体检中收集一般资料，应用Cockcroft公式与亚洲人骨质疏松自我筛查工具（OSTA）筛查出内生肌酐清除率轻度减退伴骨质疏松高危人群。应用双能X线吸收仪（DXA）测定左股骨颈骨密度值（LFN BMD），同时测定血生化指标及骨生化、代谢转换指标。结果 共筛选出236例骨质疏松高危老年人群，平均年龄为（77.40±5.46）岁。logistic多元回归分析显示OSTA指数、血清25羟维生素D₃与骨质疏松呈负相关（OR=0.08，OR=0.65），甲状旁腺激素（PTH）与骨质疏松呈正相关（OR=1.54）。结论 OSTA指数适合运用在社区骨质疏松高危老年人群的筛查工作中，上述人群普遍存在25（OH） VitD₃缺乏，在上述人群中适当补充活性维生素D3和钙剂可延缓骨质疏松的发生。

Analysis on the relationship between osteoporosis and biochemical marks of bone metabolism in aged people with high risk of osteoporosis

Objective To explore the relationship between osteoporosis and biochemical marks of bone metabolism in aged people with high risk of osteoporosis. Methods General information of the aged people older than 65 were collected from the health examinations. Cockcroft formula and OSTA index were used to screen high risk population of osteoporosis combined with slight decrease of endogenous creatinine clearance rate. The left femoral neck bone mineral density was detected by dual-energy X ray absorptiometry (DXA). Meanwhile, blood biochemical indicators, biochemical markers of bone metabolism was detected. Results A total of 236 high risk elderly patients with osteoporosis with the average age of 77.40±5.46 years were detected. Logistic regression analysis showed that OSTA and 25(OH)VitD₃ were negative correlation with osteoporosis (OR=0.08, OR=0.65). The level of PTH was positive correlation with osteoporosis(OR=1.54). Conclusion OSTA index is suitable for screening high risk elderly patients with osteoporosis. 25(OH)VitD₃ insufficiency is highly prevalent in this population. Appropriate supplementary of active Vitamin D and calcium is important to the above crowd to reduce the risk of osteoporosis.