脑源性神经营养因子与抑郁症共病2型糖尿病的关系研究

目的 分析脑源性神经营养因子(BDNF)对抑郁症共病2型糖尿病发病及预后的影响,了解BDNF水平变化是否是2型糖尿病和抑郁症共同的相关因素。方法 收集45例抑郁症伴2型糖尿病患者资料(DDM组),同时收集41例抑郁症不伴2型糖尿病患者资料(NDDM组),以45例健康体检人群资料作为对照组。采集各组心理量表得分、糖代谢指标、体检指标、糖尿病并发症情况及治疗前后BDNF含量,并通过构建Logistic回归模型,探讨血清BDNF水平是否为抑郁症和2型糖尿病的相关因素。结果 DDM组和NDDM组接受治疗后BDNF含量均高于治疗前水平,差异有统计学意义(P<0.001),表明经过抗抑郁症治疗,患者血清BDNF水平明显升高;BDNF水平为抑郁症的保护因素,OR为0.782,95% CI(0.702~0.872),BDNF的水平越高,患抑郁症的危险性越小;年龄、空腹血糖(FPG)浓度及BDNF水平为抑郁症共病2型糖尿病患病的相关因素,其中年龄和FPG为负相关,血清BDNF为保护因素,OR为0.835,95% CI(0.736~0.948)。结论 血清BDNF浓度增高可降低抑郁症及共病2型糖尿病的风险。

Influences of BNDF in depressive patients with type 2 diabetes mellitus

Objective To analyze the role BDNF plays in depressive patients with diabetes and to explore whether BDNF is correlative risk factors in type 2 diabetes and depression.Methods A prospective case-control study was done in which 45 depressive patients with 2 type diabetes (DDM group) and 41 without diabetes(NDDM) were in cluded. The health control group consisted of 45 healthy people. Demographic data, psychological scale, sugar metabolism, diabetes complications, medical indicators and serum brain-derived neurotrophic factor levels before and after treatment were collected and Logistic regression models constructed.Results BDNF in DDM Group and NDDM groups was of statistical difference before and after treatment(P<0.001). After treatment BDNF levels were higher than those before treatment levels, indicating that after the adoption of antidepressant treatment, serum BDNF levels improved significantly; for patients with depression, BDNF levels were found to be protective factors for depression, OR=0.782,95% CI (0.702-0.872), and with higher levels of BDNF, the risk of suffering from depression became smaller; with age, FPG and BDNF levels in depression with type 2 diabetes, age and FPG were risk factors for the disease, while serum BDNF was a protective factor, OR=0.835,95% CI (0.736-0.948).Conclusion BDNF proves to be one of the important biological factors for type 2 diabetes and depression co-morbidity and its higher levels are protective factors for the disease. In this study, serum BDNF has been investigated to obtain a basis for reference in this regard.