针刺对肺癌手术患者肿瘤坏死因子水平的影响

目的　探讨针刺对肺癌手术患者血清肿瘤坏死因子 (TNF)水平变化及免疫机制的影响。方法　采用双抗体夹心免疫酶标法 (EL TSA)检测肺癌患者血清中肿瘤坏死因子含量 ;针药麻组与全麻组肺癌手术患者各 2 5例 ,分别在术前、术后第 1d、术后第 8d测量 TNF含量作比较。结果　血清中肿瘤坏死因子含量在术前和术后第 1d作两组比较 ,无显著差异 (P>0 .0 5 ) ;在术后第 8d作两组比较 ,有显著性差异 (P<0 .0 5 ) ,针药麻组明显优于全麻组。结论　针刺能降低肺癌手术患者血清中肿瘤坏死因子含量 ,对肺癌手术患者有免疫调节功能。

The Influence of Acupuncture on Tumor Necrosis Factor Level in Patients Undergoing an Operation for Lung Cancer

Objective To investigate the effect of acupuncture on serum tumor necrosis factor (TNF)level and immunological mechanism in patients undergoing an operation for lung cancer. Methods Double antibody enzyme labeled immunoassay was used to determine the tumor necrosis factor content of serum in patients undergoing an operation for lung cancer. Before,and at 1 day and 8 days after an operation for lung cancer, TNF content was determined and compared in an acupuncture anesthesia group and a general anesthesia group of patients undergoing the operation ,25 cases each.Results There was no significant difference in the tumor necrosis factor content of serum before and at 1 day after the operation (P>0.05) but there was at 8 days after the operation (P<0.05) between the two groups. The effect was better in the acupuncture anesthesia group than in the general anesthesia group.Conclusion Acupuncture can decrease the tumor necrosis factor content of serum and regulate immunological function in patients undergoing an operation for lung cancer.