Evaluation of effects of T and N type calcium channel blockers on the electroencephalogram recordings in Wistar Albino Glaxo/Rij rats,an absence epilepsy model |
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| Authors: | Nedim Durmus Sefa Gültürk Tijen Kaya Tuncer Demir Mesut Parlak Ahmet Altun |
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| Affiliation: | Department of Medical Pharmacology, Hacettepe University Medical Faculty, Ankara, Turkey;1Department of Physiology, Cumhuriyet University Medical Faculty, Sivas, Turkey;2Department of Medical Pharmacology, Katip Celebi University Medical Faculty, İzmir, Turkey;3Department of Physiology, Gaziantep University Medical Faculty, Gaziantep, Turkey;4Department of Medical Pharmacology, Cumhuriyet University Medical Faculty, Sivas, Turkey |
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| Abstract: | Objectives:It is suggested that excessive calcium entry into neurons is the main triggering event in the initiation of epileptic discharges. We aimed to investigate the role of T and N type calcium channels in absence epilepsy experimental model.Results:Beta and delta recording ratios in 1 μM/5 μl mibefradil group was significantly different from basal and other dose-injected groups. Beta, alpha, and theta recordings in 0.2 μM/5 μl w-Conotoxin MVIIA group was significantly different from basal and other dose-injected groups. In w-Conotoxin MVIIA after mibefradil group, beta, alpha, and theta recording ratios were significantly different from basal and mibefradil group. Mibefradil and w-Conotoxin MVIIA significantly decreased the frequency and duration of SWDs. The decrease of frequency and duration of SWDs in mibefradil group was significantly different from w-Conotoxin MVIIA group. The frequency and duration of SWDs significantly decreased in w-Conotoxin MVIIA after mibefradil group compared with basal, mibefradil, and w-Conotoxin MVIIA groups.Conclusions:We concluded that both T and L type calcium channels play activator roles in SWDs and have positive effects on frequency and duration of these discharges. These results are related with their central effects more than peripheral effects.KEY WORDS: Epilepsy, mibefradil, T and N type calcium channels, Wistar Albino Glaxo/Rij rats, w-Conotoxin MVIIA |
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