Enhancement of nootropic effect of duloxetine and bupropion by caffeine in mice |
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| Authors: | Pravin Popatrao Kale Veeranjaneyulu Addepalli |
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| Affiliation: | 1Department of Pharmacology, SPP SPTM, SVKM''s NMIMS, Maharashtra, India;2Department of Pharmacology, Dr. Bhanuben Nanavati College of Pharmacy, Mumbai, Maharashtra, India |
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| Abstract: | Objective:The existing evidence suggests an association between depression and memory impairment. The objective of present study was to assess the effect of low dose caffeine with duloxetine and bupropion on memory.Results:Caffeine with duloxetine treated group was better than other combination treated groups in terms of a significant decrease in TL and increase in the time spent in target quadrant recorded.Conclusion:Combining lower dose of caffeine with duloxetine may enhance cognitive benefits than respective monotherapies.KEY WORDS: And bupropion, caffeine, duloxetine, memory |
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