Comparison of the efficacy of liraglutide with pioglitazone on dexamethasone induced hepatic steatosis,dyslipidemia and hyperglycaemia in albino rats |
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| Authors: | K. Vinodraj I. M. Nagendra Nayak J. Vikram Rao Paul Mathai N. Chandralekha B. Nitasha D. Rajesh T. K. Chethan |
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| Affiliation: | Department of Pharmacology, K. S. Hegde Medical Academy, Deralakatte, Mangalore, Karnataka, India;1Department of Community Medicine, K. S. Hegde Medical Academy, Deralakatte, Mangalore, Karnataka, India |
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| Abstract: | Objectives:To evaluate the efficacy of liraglutide with pioglitazone for prevention of dexamethasone induced hepatic steatosis, dyslipidemia and hyperglycemia in Albino rats.Results:Dexamethasone caused hepatomegaly, dyslipidemia, and hyperglycemia. Both pioglitazone and liraglutide significantly reduced hepatomegaly, dyslipidemia and hyperglycemia (P < 0.01). Reduction of blood sugar levels after glucose load was significant with pioglitazone when compared with liraglutide (P < 0.01).Conclusion:Liraglutide has comparable efficacy to pioglitazone in prevention of dexamethasone induced hepatomegaly, dyslipidemia and fasting hyperglycemia.KEY WORDS: Dexamethasone, hepatomegaly, hyperglycemia, liraglutide, pioglitazone, prevention |
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