A Malignant Transformation of a Spinal Epidural Mass from Ganglioneuroblastoma to Neuroblastoma |
| |
| Authors: | Mehmet Osman Akcakaya Bilge Bilgic Yavuz Aras Nail Izgi |
| |
| Affiliation: | 1Department of Neurosurgery, School of Medicine, Istanbul University, Istanbul, Turkey.;2Department of Pathology, School of Medicine, Istanbul University, Istanbul, Turkey. |
| |
| Abstract: | Ganglioneuromas are benign tumors. Surgical excision is the treatment of choice with very good prognosis. However, neuroblastomatous malignant transformation of ganglioneuromas was previously reported. We report a patient with spinal neuroblastoma recurrent from a ganglioneuroblastoma after disease free survival of 13 years. This is one of the rare examples of spinal neuroblastoma and to our knowledge the second case report with malignant transformation from a ganglioneuroblastoma or a ganglioneuroma. The present case is the only report in the literature with further genetic investigations. |
| |
| Keywords: | Ganglioneuroblastoma Neuroblastoma Malignant transformation Spinal tumor |
|
|
