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Forward and reverse degradomics defines the proteolytic landscape of human knee osteoarthritic cartilage and the role of the serine protease HtrA1
Affiliation:2. Department of Biomedical Engineering, Cleveland Clinic Lerner Research Institute, Cleveland, OH, USA;3. Proteomics and Metabolomics Core, Cleveland Clinic Lerner Research Institute, Cleveland, OH, USA;4. Department of Orthopaedic Surgery, Cleveland Clinic Orthopaedic and Rheumatologic Institute, Cleveland, OH, USA;2. Nantes Université, Oniris, CHU Nantes, INSERM, Regenerative Medicine and Skeleton, RMeS, UMR 1229, F-44000 Nantes, France;3. Centre for Experimental Medicine & Rheumatology, William Harvey Research Institute and Barts and the London School of Medicine and Dentistry, Queen Mary University of London, LRondon, UK;4. Nantes Université, CHU Nantes, INSERM UMS 016, CNRS 3556, Structure Fédérative de Recherche François Bonamy, SC3M Facility, F-44000 Nantes, France;6. Nantes Université, INSERM, Center for Research in Transplantation and Translational Immunology, UMR 1064, ITUN(3), F-44000 Nantes, France;5. IRMB, Univ Montpellier, INSERM, Montpellier, France;2. Department of Rheumatology, Lille Catholic Hospitals and Lille Catholic University, Lille, France;3. Univ. Lille, CHU Lille, Univ. Littoral Côte D''Opale, ULR 4490 - MABLab- Adiposité Médullaire et Os, F-59000 Lille, France;4. Univ. Lille, CHU Lille, ULR 4490, Department of Rheumatology, 59000 Lille, France;6. Department of Orthopaedic Surgery, Lille Catholic Hospitals and Lille Catholic University, Lille, France;5. Department of Orthopaedic Surgery, CHU Lille, Lille University, Lille, France;11. Department of Diagnostic and Interventional Radiology, Lille Catholic Hospitals and Lille Catholic University, Lille, France;12. Department of Research, Biostatistics, Lille Catholic Hospitals and Lille Catholic University, Lille, France;8. Biomechanics Lab - Institute of Mechanics, Materials, and Civil Engineering, Louvain-la-Neuve, UCLouvain, Belgium;10. IREC – Institute of Experimental and Clinical Research, UCLouvain, Woluwe, Belgium;9. Department Materials Engineering, Leuven, KU Leuven, Belgium;2. Center for Molecular Medicine, Department of Medicine Solna, Karolinska Institutet, and Division of Rheumatology, Karolinska University Hospital, SE-171 76 Stockholm, Sweden;3. Lund University, Faculty of Medicine, Department of Clinical Sciences Lund, Orthopaedics, Lund, Sweden;4. University of Muenster, Institute of Immunology, Münster, Germany;6. Clinical Studies Sweden, Forum South, Skåne University Hospital, Lund, Sweden;5. Broegelmann Research Laboratory, Department of Clinical Science, University of Bergen, Bergen, Norway;2. Department of Orthodontics, Peking University School and Hospital of Stomatology, Beijing, China;3. National Clinical Research Center for Oral Diseases & National Engineering Laboratory for Digital and Material Technology of Stomatology, Beijing, China;4. Beijing Key Laboratory of Digital Stomatology, 22# Zhongguancun South Avenue, Haidian District, Beijing, 100081, China;5. Central Laboratory, Peking University School and Hospital of Stomatology, Haidian District, Beijing, China
Abstract:
Keywords:Cartilage  Proteomics  Degradomics  Proteolysis  Proteases  Mass spectrometry  HtrA1  Osteoarthritis  Extracellular matrix
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