Effect of intravitreal ranibizumab on serous retinal detachment in diabetic macular edema |
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| Institution: | 1. Department of Pediatrics, College of Medicine, Qassim University, Qassim 51452, Saudi Arabia;2. Division of Pediatric Endocrinology and Diabetes, Department of Pediatrics, Louisiana State University Health Sciences Center, New Orleans, LA 70118, USA;3. Children''s Hospital of New Orleans, New Orleans, LA 70118, USA;1. Joslin Diabetes Center, Harvard Medical School, Boston, MA;2. VA Ann Arbor Healthcare System, Michigan Medicine, Department of Psychiatry, Ann Arbor, MI;3. Department of Pediatrics, Stanford University School of Medicine, Palo Alto, CA;4. Ferkauf Graduate School of Psychology, Yeshiva University, Bronx, NY;5. Departments of Medicine (Endocrinology) and Epidemiology & Population Health, Albert Einstein College of Medicine, Bronx, NY;1. 3rd Department of Internal Medicine, First Faculty of Medicine, Charles University in Prague and General University Hospital in Prague, Czech Republic;2. Institute of Medical Biochemistry and Laboratory Diagnostics, First Faculty of Medicine, Charles University in Prague and General University Hospital in Prague, Czech Republic;1. Department of Endocrinology and Diabetes, St Vincent''s Hospital Melbourne, Fitzroy, Victoria, Australia;2. Department of Medicine, University of Melbourne, Fitzroy, Victoria, Australia;3. St Vincent''s Institute of Medical Research, Fitzroy, Victoria, Australia;4. Department of Public Health, La Trobe University, Australia;5. Australian Centre for Accelerating Diabetes Innovations, University of Melbourne, Australia;1. Clinical Research Unit, Khoo Teck Puat Hospital (KTPH), Singapore;2. Gerontology Research Programme, Department of Psychological Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore;3. Department of Geriatric Medicine, Khoo Teck Puat Hospital (KTPH), Singapore;4. National Healthcare Group Polyclinics (NHGP), Singapore;5. Diabetes Centre, Admiralty Medical Centre (AdMC), Singapore;6. Saw Swee Hock School of Public Health, National University of Singapore (NUS), Singapore |
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| Abstract: | PurposeTo evaluate the functional and anatomical results of intravitreal ranibizumab (IVR) treatment in diabetic macular edema (DME) with and without serous retinal detachment (SRD).Material and methodsFifty-one eyes treated with three consecutive intravitreal injections of ranibizumab for DME with and without SRD were retrospectively analyzed. Patients were divided into two groups according to optical coherence tomography (OCT) findings. Group 1 consisted of 25 DME patients with SRD, Group 2 consisted of 26 DME patients without SRD. After three consecutive IVR injections, changes in best-corrected visual acuity (BCVA) and central macular thickness (CMT) were analyzed and compared between groups.ResultsThe mean age was 64.16 ± 6.43 and 68.77 ± 7.19 years, respectively (p = 0.036). Initial BCVA was 0.55 ± 0.36, 0.62 ± 0.39 LogMAR, respectively (p: 0.613). Initial CMT was 548.7 ± 111.6 μm, 446.4 ± 104.1 μm in groups, respectively and it was significantly higher in Group 1 (p = 0.001). After three consecutive IVR, mean BCVA improved to 0.47 ± 0.30 LogMAR (p = 0.281) and CMT decreased to 331.6 ± 165.1 μm (p = 0.000) in Group 1. Mean BCVA improved to 0.40 ± 0.34 LogMAR (p = 0.005) and CMT decreased to 287.2 ± 148.8 μm (p = 0.000) in Group 2. While the decrease in CMT values was similar between the groups, the increase in BCVA was more pronounced in Group 2 after IVR treatment.ConclusionsSimilar morphological results were obtained in both of the groups, but the visual gain was lower in patients with SRD. |
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