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Association between epicardial adipose tissue and left ventricular function in type 2 diabetes mellitus: Assessment using two-dimensional speckle tracking echocardiography |
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| Institution: | 1. Department of Laboratory Medicine, Nanjing First Hospital, Nanjing Medical University, Nanjing, Jiangsu 210006, China;2. Department of Echocardiography, Nanjing First Hospital, Nanjing Medical University, Nanjing, Jiangsu 210006, China;1. Department of Endocrinology, St. Stephen''s Hospital, Delhi, India;2. Senior Biostatistician, Dr BRA IRCH, AIIMS, Delhi, India;3. Department of Obstetrics and Gynecology, St. Stephen''s Hospital, Delhi, India;4. Department of Reproductive Medicine, St. Stephen''s Hospital, Delhi, India;5. Department of Paediatrics and Neonatology, St. Stephen''s Hospital, Delhi, India;1. Department of Ophthalmology, Calcutta National Medical College, 32 Gorachand Road, Kolkata 700014, India;2. Department of Radiology, Bangur Institue of Neurosciences, 52/1a, Sambhunath Pandit St, Gokhel Road, Bhowanipore, Kolkata 700020, India;1. Department of Cardiology, Peking University First Hospital, Beijing, China;2. Institute of Cardiovascular Disease, Peking University First Hospital, Beijing, China |
| Abstract: | Background and aimsEpicardial adipose tissue (EAT) is the visceral fat between the myocardium and the visceral pericardium. Dysfunctional EAT can cause cardiovascular diseases. The aim of this study was to investigate the association between EAT and left ventricular function in type 2 diabetes mellitus (T2DM) patients by two-dimensional speckle tracking echocardiography (2D-STE).MethodsWe prospectively enrolled 116 T2DM patients who were divided into two groups according to their left ventricular global longitudinal strain (GLS): 53 with GLS <18% and 63 with GLS ≥18%. The thickness of EAT was measured as the echo-free space between the free wall of the right ventricle and the visceral layer of pericardium at end-systole. LV systolic function was evaluated by GLS measured by 2D-STE. LV diastolic function was defined as the ratio of the early diastolic transmitral flow velocity (E) to average mitral annular velocity ().ResultsCompared with patients with GLS ≥18% group, the age, body mass index (BMI), waist circumference (WC), systolic blood pressure (SBP), diastolic blood pressure (DBP), low-density lipoprotein cholesterol (LDL-C), glycosylated hemoglobinA1c (HbA1c), E/, and thickness of EAT were higher in patients with GLS <18% group (all P < 0.05). Multivariate linear regression analysis revealed that the thickness of EAT was independently associated with left ventricular GLS and E/.ConclusionsThickened EAT is associated with impaired left ventricular function in T2DM patients. To investigate the association between EAT and left ventricular function can help us gain a deeper understanding of the pathogenesis of impaired cardiac function in T2DM patients. |
| Keywords: | T2DM"} {"#name":"keyword" "$":{"id":"kw2010"} "$$":[{"#name":"text" "_":"type 2 diabetes mellitus EAT"} {"#name":"keyword" "$":{"id":"kw4010"} "$$":[{"#name":"text" "_":"epicardial adipose tissue 2D-STE"} {"#name":"keyword" "$":{"id":"kw6010"} "$$":[{"#name":"text" "_":"two-dimensional speckle tracking technology LVEF"} {"#name":"keyword" "$":{"id":"kw8010"} "$$":[{"#name":"text" "_":"left ventricular ejection fraction GLS"} {"#name":"keyword" "$":{"id":"kw1010"} "$$":[{"#name":"text" "_":"global longitudinal strain SBP"} {"#name":"keyword" "$":{"id":"kw1210"} "$$":[{"#name":"text" "_":"systolic blood pressure DBP"} {"#name":"keyword" "$":{"id":"kw1410"} "$$":[{"#name":"text" "_":"diastolic blood pressure TCH"} {"#name":"keyword" "$":{"id":"kw1610"} "$$":[{"#name":"text" "_":"total cholesterol TG"} {"#name":"keyword" "$":{"id":"kw1810"} "$$":[{"#name":"text" "_":"triglycerides LDL-C"} {"#name":"keyword" "$":{"id":"kw8110"} "$$":[{"#name":"text" "_":"low-density lipoprotein cholesterol UA"} {"#name":"keyword" "$":{"id":"kw2210"} "$$":[{"#name":"text" "_":"urine microalbumin CR"} {"#name":"keyword" "$":{"id":"kw2410"} "$$":[{"#name":"text" "_":"urinary creatinine LAD"} {"#name":"keyword" "$":{"id":"kw2610"} "$$":[{"#name":"text" "_":"left atrial diameter IVSD"} {"#name":"keyword" "$":{"id":"kw2810"} "$$":[{"#name":"text" "_":"interventricular septal thickness in end-diastolic period LVPWD"} {"#name":"keyword" "$":{"id":"kw3110"} "$$":[{"#name":"text" "_":"left ventricular posterior wall thickness in end-diastolic period LVEDD"} {"#name":"keyword" "$":{"id":"kw3310"} "$$":[{"#name":"text" "_":"left ventricular end-diastolic diameter LVESD"} {"#name":"keyword" "$":{"id":"kw3510"} "$$":[{"#name":"text" "_":"left ventricular end-systolic diameter E"} {"#name":"keyword" "$":{"id":"kw3710"} "$$":[{"#name":"text" "_":"early diastolic mitral inflow velocity A"} {"#name":"keyword" "$":{"id":"kw3910"} "$$":[{"#name":"text" "_":"late diastolic mitral inflow velocity e¯"} {"#name":"keyword" "$":{"id":"kw4210"} "$$":[{"#name":"text" "_":"average mitral annular velocity ACEi/ARB"} {"#name":"keyword" "$":{"id":"kw4410"} "$$":[{"#name":"text" "_":"angiotensin converting enzyme inhibitor/angiotensin II receptor blockers CCB"} {"#name":"keyword" "$":{"id":"kw4610"} "$$":[{"#name":"text" "_":"calcium channel blockers SGLT-2I"} {"#name":"keyword" "$":{"id":"kw4810"} "$$":[{"#name":"text" "_":"sodium–glucose co-transporter-2 inhibitors DPP-4I"} {"#name":"keyword" "$":{"id":"kw5210"} "$$":[{"#name":"text" "_":"dipeptidyl peptidase-4 inhibitor GLP-1RA"} {"#name":"keyword" "$":{"id":"kw4510"} "$$":[{"#name":"text" "_":"glucagon like peptide-1receptor agonist |
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