Atrial fibrillation is associated with poor long-term outcome after mechanical thrombectomy for anterior large vessel occlusion stroke |
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| Institution: | 1. Neurology Clinic, University Clinical Center of Serbia, Dr Subotica Street 6, Belgrade 11 000, Serbia;2. Institute of Epidemiology, Faculty of Medicine, Vi?egradska Street 26, Belgrade 11 000, Serbia;3. Faculty of Medicine, Dr Subotica Street 8, Belgrade 11 000, Serbia;4. Center for Radiology and MRI, Clinic for Neurosurgery, University Clinical Center of Serbia, Pasterova 2, Belgrade 11000, Serbia;1. Department of Endocrinology, Beijing Chaoyang Hospital, Capital Medical University, PR China;2. Department of Neurology, Beijing Chaoyang Hospital, Capital Medical University, No. 8, South Gongti Road, Beijing 100020, PR China;1. Division of Vascular Neurology, Department of Neurology University of Utah, Salt Lake City, UT, USA;2. Department of Neurology, Mayo Clinic Florida, Jacksonville, FL, USA;3. Department of Neurology, Yale University School of Medicine, New Haven, CT, USA;4. Division of Stroke and Cerebrovascular Diseases, Department of Neurology, The Warren Alpert Medical School of Brown University, 593 Eddy St, APC Bldg, 5th floor, Providence 02903, RI, USA;1. Kwame Nkrumah University of Science and Technology, Kumasi, Ghana;2. University of California, San Francisco, CA, USA;3. College of Medicine, University of Ibadan, Ibadan, Nigeria;4. University of Ghana Medical School, Accra, Ghana;5. University of Ilorin Teaching Hospital, Nigeria;6. Ahmadu Bello University, Zaria, Nigeria;7. Obafemi Awolowo University Teaching Hospital, Ile-Ife, Nigeria;8. Aminu Kano Teaching Hospital, Nigeria;9. Delta State University Teaching Hospital, Ogara, Nigeria;10. Medical University of South Carolina, SC, USA;11. University of Kentucky, USA;12. University of Alabama at Birmingham, Birmingham, USA;13. Federal Medical Centre, Abeokuta, Nigeria;1. Department of Neurosurgery, Soonchunhyang University Bucheon Hospital, 170, Jomaru-ro, Bucheon, Gyeonggi-Do 14584, Republic of Korea;2. Department of Neurosurgery, College of Medicine, St. Vincent''s Hospital, The Catholic University of Korea, Seoul, Republic of Korea;3. Department of Neurosurgery, Hangang Sacred Heart Hospital, Hallym University, Seoul, Republic of Korea |
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| Abstract: | ObjectivesAtrial fibrillation (AF) is one of the leading causes of acute ischemic stroke (AIS). The aim of our study was to determine the influence of AF on the long-term outcome of patients with AIS due to anterior circulation large vessel occlusion (LVO) treated with mechanical thrombectomy (MT).MethodsOur study included 127 consecutive patients with AIS due to anterior LVO who underwent MT between January 2018 and March 2020. Demographics, clinical, radiological and treatment characteristics were prospectively collected. Modified Rankin scale (mRS) score ≤2 was defined as a good functional outcome.ResultsAF was detected in 62 (48.8%) patients. Patients with AF were elder (73.1 ± 8.7 vs. 58.5 ± 14.2 years, p<0.01) and usually female (56.5% vs. 36.9%, p=0.03). They had a lower percentage of good functional outcome (31.6% vs. 62.3%, p<0.01) and a higher mortality rate (47.5% vs. 18.5%, p<0.01) after one year of follow-up. In the multivariate logistic regression the variables that showed significance with p <0.05 in previous univariate analyses were included. The presence of AF (aOR 0.29, 95% CI 0.11-0.78, p=0.01) and initial NIHSS score >15 (aOR 0.25, 95% CI 0.11-0.56, p<0.01) were independent negative predictors of good functional outcome after one year of follow-up. However, the presence of AF did not affect all-cause mortality within one year (p=0.18).ConclusionAF and initial NIHSS score >15 are independent negative predictors of good long-term functional outcome in patients with AIS due to anterior circulation LVO treated with MT. |
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