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Appendix to the Society of Interventional Radiology Consensus Guidelines for the Periprocedural Management of Thrombotic and Bleeding Risk in Patients Undergoing Percutaneous Image-Guided Interventions: Pediatric Considerations
Institution:1. Department of Radiology, Boston Children’s Hospital, Harvard Medical School, Boston, Massachusetts;2. Department of Interventional Radiology, Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania;3. Division of Vascular and Interventional Radiology, Department of Radiology, Boston Children’s Hospital, Harvard Medical School, Boston, Massachusetts;4. Society of Interventional Radiology, Fairfax, Virginia;5. Department of Radiology (K.K.), Texas Children’s Hospital/Baylor College of Medicine, Houston, Texas;6. Dana Farber/Boston Children’s Cancer and Blood Disorders Center, Department of Pediatrics, Harvard Medical School, Boston, Massachusetts;7. Department of Radiology, Indiana University Health-Riley Hospital for Children, Indianapolis, Indiana;8. Department of Radiology, University of Wisconsin, Madison, Wisconsin;9. Division of Hematology, Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania;10. The Raymond G. Perelman Center for Cellular and Molecular Therapeutics, The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania;11. Division of Interventional Radiology, Department of Radiology, Boston Children’s Hospital, Harvard Medical School, Boston, Massachusetts
Abstract:PurposeTo provide guidance on the use of anticoagulant and antithrombotic agents in pediatric patients undergoing interventional radiology procedures.Materials and MethodsA multidisciplinary writing group conducted a comprehensive literature search to identify studies on the topic of interest. Recommendations were developed for procedural risk and medication dosage and withholding. A modified Delphi technique was used to achieve consensus agreement on the recommendations.ResultsA total of 24 studies, including systematic reviews and meta-analyses, randomized controlled trials, and prospective and retrospective cohort studies, were identified as relevant. The expert writing group agreed on procedural risk categorization, laboratory testing thresholds, and medication dosage and withholding recommendations specific to pediatric practice. They additionally described the nuances of anticoagulation in clinical conditions specific to pediatrics.ConclusionsThe Society of Interventional Radiology recommends following the guidance provided in the document when developing multidisciplinary management protocols for anticoagulation and antithrombotic treatment in pediatric patients undergoing interventional radiology procedures.
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