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Different changes in the biomarker C-terminal telopeptides of type II collagen (CTX-II) following intra-articular injection of high molecular weight hyaluronic acid and oral non-steroidal anti-inflammatory drugs in patients with knee osteoarthritis: a multi-center randomized controlled study
Affiliation:2. Department of Medicine for Orthopaedics and Motor Organ, Juntendo University Graduate School of Medicine, Tokyo, Japan;3. Department of Orthopaedic Surgery, University of Occupational and Environmental Health, Fukuoka, Japan;4. Department of Orthopaedic Surgery, Gifu University, School of Medicine, Gifu, Japan;6. Department of Laboratory Sciences, School of Health Sciences, Faculty of Medicine, Gunma University, Gunma, Japan;5. Department of Orthopaedic Surgery, Kinki University Sakai Hospital, Osaka, Japan;11. Center of Transdisciplinary Research, Institute for Research Promotion, Niigata University, Niigata, Japan;12. Department of Orthopaedic Surgery, Sapporo Medical University School of Medicine, Hokkaido, Japan;8. Department of Orthopaedic Surgery, Faculty of Medicine, Shimane University School of Medicine, Shimane, Japan;10. Department of Orthopaedic Surgery, Tokyo Women''s Medical University, Medical Center East, Tokyo, Japan;9. Center of Mathematics and Data Sciences, Gunma University, Maebashi, Japan
Abstract:
Keywords:Hyaluronic acid (HA)  CTX-II  Non-steroidal anti-inflammatory drugs (NSAIDs)  Knee osteoarthritis  Randomized controlled trial (RCT)
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