The association between physical activity time and neuropathy in longstanding type 1 diabetes: A cross-sectional analysis of the Canadian study of longevity in type 1 diabetes |
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| Affiliation: | 1. Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada;2. Division of Endocrinology and Metabolism, Department of Medicine, University of Toronto. Toronto, Ontario, Canada;3. Division of Nephrology, Department of Medicine, University of Toronto. Toronto, Ontario, Canada;4. Research Division, Joslin Diabetes Center. Boston, MA, USA.;5. Department of Ophthalmology and Vision Sciences, Department of Medicine, University of Toronto. Toronto, Ontario, Canada;6. Joint Department of Medical Imaging, Division of Cardiothoracic Radiology, University Health Network, Toronto, Ontario, Canada.;7. The Ellen and Martin Prosserman Centre for Neuromuscular Diseases, Krembil Neuroscience Centre, Division of Neurology, Department of Medicine, University Health Network, University of Toronto, Toronto, Ontario, Canada.;1. Department of Cardiology, Peking University First Hospital, Beijing, China;2. Institute of Cardiovascular Disease, Peking University First Hospital, Beijing, China;1. UConn School of Medicine, Farmington, CT, USA;2. UConn School of Dental Medicine, Farmington, CT, USA;3. Jaeb Center for Health Research, Tampa, FL, USA;4. Yale School of Medicine, New Haven, CT, USA;1. Dept of Genetics, Dr ALM PG IBMS, University of Madras, Taramani, Chennai, India;2. Prof. M. Viswanathan Diabetes Research Centre, Chennai, India;1. Kowloon West Cluster Laboratory Genetic Service, Department of Pathology, Princess Margaret Hospital, Hong Kong;2. Department of Medicine and Geriatrics, Princess Margaret Hospital, Hong Kong;3. Department of Medicine, Yan Chai Hospital, Hong Kong;4. Department of Medicine and Geriatrics, Caritas Medical Centre, Hong Kong;5. Health Sense Diabetes & Endocrine Centre, Hong Kong |
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| Abstract: | AimPhysical activity (PA) is recommended to improve glycemic control in T1D; however, the effect of PA on distal symmetric polyneuropathy (DSPN) and cardiac autonomic function in longstanding T1D is unknown.MethodsData from 75 participants were collected as part of the Canadian Study of Longevity in T1D. Participants completed a physical exam, medical history, extensive complications phenotyping and reported their daily PA from the preceding 12-months. Pearson and Spearman correlations were used to assess PA time and complications variables. Linear regression was used to test associations between PA time, neurological and electrophysiological measures. Univariable regression was used to indicate the change in the given independent variables associated with a 30-min increase in PA per week.ResultsParticipants were 66 ± 8 years old with diabetes duration of 54 [52,58] years, HbA1c was 7.3 ± 0.8, 65(89%) had DSPN. Weekly PA time was 156 ± 132 min, and 35(47%) reported ≧150 min/week. Participants with DSPN reported lower PA time compared to individuals without DSPN (141 ± 124 min/week vs. 258 ± 129 min/week; p = 0.015). PA time was associated with better cooling detection threshold (r = 0.24; p = 0.043), peroneal and sural amplitude (r = 0.36; p = 0.0017, rs = 0.26; p = 0.024) and conduction velocity (rs = 0.28; p = 0.015, r = 0.23; p = 0.050). Linear regression adjusting for age and HbA1c, showed that for each 30-min of PA there was a 0.09mv higher peroneal amplitude (p = 0.032) and 0.048 ms lower peroneal F-wave latency (p = 0.022).ConclusionIn longstanding T1D, PA time is associated with superior large nerve fibre function in the lower limbs and some better measures of small nerve fibre function. |
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