Analysis of Factors Associated with Hemorrhagic Transformation in Acute Cerebellar Infarction |
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| Institution: | 1. Department of Neurology, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, Shandong, China;2. Department of Neurology, Minhang Hospital, Fudan University, Shanghai, China;1. Department of Interventional Neuroradiology, Beijing Tiantan Hospital, Capital Medical University, No.119, the South Fourth Ring West Road, Fengtai district, Beijing 100070, China;2. Department of Ultrasound, Beijing Tiantan Hospital, Capital Medical University, No.119 South 4th Ring West Road, Fengtai District, Beijing 100070, China;3. The George Institute for Global Health at Peking University Health Science Center, Beijing, China;4. Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia;5. Department of Ultrasound, Huaian Hospital of Huaian City, Huaian, Jiangsu, China;1. Department of Health and Environmental Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan;2. Department of Neurosurgery, Kyoto University Graduate School of Medicine, Kyoto, Japan;3. Department of Artificial Intelligence in Healthcare and Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan;4. Social Health Medicine Welfare Laboratory, Public Interest Incorporated Association Kyoto Hokenkai, Kyoto, Japan;1. Intensive Care Unit of the Affiliated Huai''an Hospital of Xuzhou Medical University, Huai''an 223001, Jiangsu, China;2. Laboratory of Emergency Medicine, Second Clinical Medical College of Xuzhou Medical University, Xuzhou, 221004, China;3. Emergency Medicine Department of the Affiliated Hospital of Xuzhou Medical University, Xuzhou, 221002, China;1. Department of Neurology, National Cerebral and Cardiovascular Center, 6-1 Kishibe-Shimmachi, Suita, Osaka 564-8565, Japan;2. Department of Cerebrovascular Medicine, National Cerebral and Cardiovascular Center, Suita, Japan;1. Department of Neurosurgery, Nagoya University of Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, Aichi, Japan;2. Department of Transfusion Medicine, Nagoya University Hospital, Nagoya, Japan;3. Department of Integrated Health Sciences, Nagoya University Graduate School of Medicine, Nagoya, Japan;4. Department of Medical Technique, Clinical Laboratory, Nagoya University Hospital, Nagoya, Japan;1. Service d''Anesthésie-Réanimation, Hôpital Laënnec, Centre Hospitalier Universitaire, Nantes F-44093, France;2. CHU de Nantes, Inserm CIC 1413, Pôle Hospitalo-Universitaire 11: Santé Publique, Clinique des Données, Nantes, France;3. Department of Diagnostic and Therapeutic Neuroradiology, University Hospital of Nantes, Nantes F-44093, France;4. Institut du Thorax, Institut National de la Santé et de la Recherche Médicale (INSERM), Centre National de la Recherche Scientifique (CNRS), Université de Nantes, Nantes F-44093, France |
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| Abstract: | ObjectivesHemorrhagic transformation (HT) is a frequent and severe complication of ischemic stroke. This study aimed to evaluate the factors associated with the occurrence of HT in patients with acute cerebellar infarction.Materials and methodsA total of 190 patients, 141 male (74.2%) and 49 female (25.8%) with mean age 61.84 ± 12.16 years, who were admitted within 72 h of acute cerebellar infarction onset from January 2017 to March 2021 were retrospectively recruited. The multivariate logistic regression analysis was used to evaluate the independent influent factors for HT and receiver-operating characteristic (ROC) curve was applied to calculate the predictive value of those factors for HT in patients with acute cerebellar infarction.Results37 out of 190 recruited patients (19.47%) had HT within 14 days after acute cerebellar infarction onset. The incidence rates of HT occurring within 3 days, 3–7 days and 7–14 days were 13.5%, 40.5% and 45.9%, respectively. Results of the multivariable logistic regression analysis indicated that atrial fibrillation (AF) (OR 6.196, 95% CI 1.357-28.302, P = 0.019), infarct diameter (OR 5.813, 95% CI 2.932-11.526, P < 0.001), white matter hyperintensity (WMH) (OR 2.44, 95% CI 1.134–5.252, P = 0.023) were independent risk factors for HT in acute cerebellar infarction, while lymphocyte count (OR 0.319, 95% CI 0.142-0.716, P = 0.006) showed an independently protective effect.ConclusionsInfarct diameter, AF and WMH are independent risk factors for HT in patients with acute cerebellar infarction, while the lymphocyte count is a protective factor. |
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