| Institution: | 1. Department of Geriatrics, The Third Affiliated Hospital of Soochow University, Changzhou, China;2. Department of Neurology, The Third Affiliated Hospital of Soochow University, Changzhou, China;1. Department of Neurosurgery and Brain and Nerve Research Laboratory, The First Affiliated Hospital of Soochow University, Jiangsu, China;2. Department of Neurosurgery, Brigham and Women''s Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA;3. Department of Neurosurgery, Amsterdam University Medical Centers, Amsterdam, the Netherlands;4. Department of Radiology, Brigham and Women''s Hospital, Boston, MA, USA;5. Reveal Pharmaceuticals, Cambridge, MA, USA;6. Research Information Systems and Computing, Mass General Brigham, Boston, MA, USA;7. Boston Children''s Hospital Informatics Program, Boston, MA, USA;8. Department of Computer Science, Loyola University, Chicago, IL, USA;9. Division of Rheumatology, Immunology and Allergy, Brigham and Women''s Hospital, Boston, MA, USA;10. Department of Neurology, Massachusetts General Hospital, Boston, MA, USA;11. Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, USA;12. Channing Division of Network Medicine, Brigham and Women''s Hospital, Boston, MA, USA;1. Faculty of Kinesiology and Physical Education, University of Toronto, Toronto, Ontario, Canada;2. KITE Research Institute-Toronto Rehabilitation Institute, University Health Network, Toronto, Canada;3. Rehabilitation Sciences Institute, University of Toronto, Toronto, ON, Canada;4. Heart and Stroke Foundation Canadian Partnership for Stroke Recovery, Toronto, ON, Canada;1. Department of Neurology, Korea University Ansan hospital, Korea University College of Medicine, Ansan, South Korea;2. Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea;3. Department of Radiology and Research, Institute of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea;1. Department of Neurology, Biomedical Research Institute Sant Pau, Hospital de la Santa Creu i Sant Pau, Carrer Sant Quintí 89, Barcelona 08041, Spain;2. Department of Neurology, Donostia University Hospital, San Sebastián, Gipuzkoa, Spain;1. Department of Neurosurgery and Neurooncology, First Faculty of Medicine, Charles University in Prague and Military University Hospital Prague, Czech Republic;2. Department of Pathology, Third Faculty of Medicine – Charles University, Prague, Czech Republic;3. Department of Neurosurgery, University Hospital and Ostrava University Medical Faculty, Ostrava, Czech Republic;4. Department of Neurology –Second Faculty of Medicine, Charles University and University Hospital Motol, Prague, Czech Republic;5. University Hospital and Ostrava University Medical Faculty, Ostrava, Czech Republic;6. Center for Health Research, Medical Faculty, Ostrava University, Ostrava, Czech Republic;7. U Vojenské nemocnice 1200/2, Prague 6, 16000, Czechia |
| Abstract: | ObjectivesObservational studies have shown that elevated circulating cardiac troponin I (cTnI) concentrations were linked to higher risk of stroke and atrial fibrillation, but the causality remains unclear. Therefore, we used mendelian randomization to assess the potential causal effects of cTnI concentrations on the risk of stroke, its subtypes and atrial fibrillation.Materials and methodsThe instrumental variables for circulating cTnI concentrations were selected from a genome-wide association study meta-analysis of 48,115 European individuals. We examined the associations of circulating cTnI concentrations with stroke, ischemic stroke, ischemic stroke subtypes (cardioembolic, large artery, small vessel stroke), intracerebral hemorrhage and atrial fibrillation.ResultsGenetically predicted elevated circulating cTnI concentrations were associated with higher risk of cardioembolic stroke (odds ratio OR], 1.80; 95% confidence interval CI], 1.20–2.68; P = 0.004), but not associated with large artery stroke, small vessel stroke, total stroke, ischemic stroke and intracerebral hemorrhage. Additionally, we also found that elevated cTnI concentrations were causally linked to higher risk of atrial fibrillation (OR, 1.30; 95% CI, 1.10–1.53; P = 0.003).ConclusionsThis study provides evidence that genetically predicted circulating cTnI concentrations are causally linked to higher risk of cardioembolic stroke and atrial fibrillation. |
