Impact of hepatitis B virus infection on maternal and infant outcomes of women with gestational diabetes mellitus: A three-year retrospective study |
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| Institution: | 1. School of Nursing, Wuhan University, No.115, Donghu Road, Wuchang District, Wuhan, 430071, Hubei Province, China;2. Obstetrics Department, Chongqing Health Center for Women and Children, No.120, Longshan Road, Yubei District, 400021, Chongqing Province, China;1. Department of Pediatrics, College of Medicine, Qassim University, Qassim 51452, Saudi Arabia;2. Division of Pediatric Endocrinology and Diabetes, Department of Pediatrics, Louisiana State University Health Sciences Center, New Orleans, LA 70118, USA;3. Children''s Hospital of New Orleans, New Orleans, LA 70118, USA;1. Department of Biomedical Engineering and Physics, Amsterdam University Medical Centers, Amsterdam Cardiovascular Sciences, University of Amsterdam, the Netherlands;2. Department of Radiology, Leiden University Medical Center, Leiden, the Netherlands;3. Department of Epidemiology & Datascience, Amsterdam Public Health Research Institute, Amsterdam UMC, VU University Medical Center, Amsterdam, the Netherlands;4. Division of Mathematical & Statistical Methods – Biometris, Wageningen University & Research, Wageningen, the Netherlands;5. Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands;6. Department of Cardiology, Leiden University Medical Center, the Netherlands;7. Department of Radiology, University Medical Center Utrecht, Utrecht, the Netherlands;8. Department of Cardiology, Amsterdam University Medical Centers, Amsterdam Cardiovascular Sciences, University of Amsterdam, the Netherlands;1. Department of Endocrinology and Diabetes, St Vincent''s Hospital Melbourne, Fitzroy, Victoria, Australia;2. Department of Medicine, University of Melbourne, Fitzroy, Victoria, Australia;3. St Vincent''s Institute of Medical Research, Fitzroy, Victoria, Australia;4. Department of Public Health, La Trobe University, Australia;5. Australian Centre for Accelerating Diabetes Innovations, University of Melbourne, Australia;1. Nutrition-Diabetology, CHU de Bordeaux, Hôpital Haut-Lévêque, F-33600 Pessac, France;2. INSERM U1219 – Bordeaux Population Health Research Center, F-33000 Bordeaux, France |
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| Abstract: | AimsTo explore the impact of HBV infection on maternal and infant outcomes of GDM women.MethodsWe retrospectively identified 8126 women with GDM in China from July 2017 to June 2020, and divided them into GDM with HBV infection group (n = 483) and GDM with non-HBV infection group (n = 7643). Two sample t-test and Chi-square test were used to compare differences between groups. Logistic regression models were used to explore the association between HBV infection and maternal and infant outcomes.ResultsPlacental abruption (PA), (2.3% vs. 1.0%, P = 0.008), placenta previa (4.3% vs. 2.8% p = 0.044), intrahepatic cholestasis of pregnancy (ICP), (6.4% vs. 3.0%, P < 0.001), cesarean section (52.0% vs. 46.0%, P = 0.011), fetal chromosomal abnormalities (1.2% vs. 0.4%, P = 0.021), and neonatal hyperglycemia (1.9% vs. 3.6%, P = 0.047) were more likely to occur in GDM with HBV infection group. After adjusting for the covariates, HBV infection was found to be associated with ICP (aOR, 2.35; 95% CI: 1.58–3.50]), PA (aOR, 2.34; 95% CI: 1.22–4.47), and fetal chromosomal abnormalities (aOR, 2.88; 95% CI: 1.18–7.03).ConclusionsHBV infection was associated with part of maternal and infant outcomes in the GDM population. |
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