| DNA拓扑异构酶和端粒酶与白血病多药耐药关系 |
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| 引用本文： | 李守娟,顾健. DNA拓扑异构酶和端粒酶与白血病多药耐药关系[J]. 中国实验血液学杂志, 2007, 15(1): 207-210 |
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| 作者姓名： | 李守娟 顾健 |
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| 作者单位： | 扬州大学临床医学院,扬州市血液研究所,扬州,225001 |
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| 基金项目： | 江苏省医学科技发展基金 |
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| 摘 要： | 肿瘤细胞产生耐药性成为许多肿瘤治疗成败的关键，也是血液肿瘤化疗失败的重要原因，目前人们从不同的角度和水平对耐药的发生机制、逆转耐药的药物研究及相应的体内外实验等进行研究，指出多药耐药是多种因素共同作用的结果。近年来白血病的不典型耐药机制日益受到人们的重视，因此本文从DNA拓扑异构酶和端粒酶与白血病耐药的关系出发，阐述了白血病细胞多药耐药的抗凋亡机制，旨在为逆转白血病耐药及开发有效的逆转剂奠定理论基础。
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| 关 键 词： | DNA拓扑异构酶 端粒酶 白血病 多药耐药 |
| 文章编号： | 1009-2137（2007）01-0207-04 |
| 收稿时间： | 2006-03-13 |
| 修稿时间： | 2006-11-08 |
DNA Topoisomerase and Telomerase Activity with Relation to Multi-Drug Resistance in Leukemia——Review |
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| LI Shou-Juan,GU Jian. DNA Topoisomerase and Telomerase Activity with Relation to Multi-Drug Resistance in Leukemia——Review[J]. Journal of experimental hematology, 2007, 15(1): 207-210 |
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| Authors: | LI Shou-Juan GU Jian |
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| Affiliation: | Institute of Hematology, Clinical Medical College, Yangzhou University, Yangzhou 225001, China. |
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| Abstract: | The appearance of multi-drug resistance becomes a key to treat many malignanccies, and also is an important factor in the failure of chemotherapy. Presently, the studies on multi-drug resistance mechanism, reversor and associated exterior experiments in vivo and in vitro from different points of view and levels show that multi-drug resistance is the result of common action in many factors. In recent years non-representative mechanism of multi-drug resistance becomes more and more significant. This review aims at establishing rationale basis for reversing multi-drug resistance of leukemia and finding effective reversors by expounding the mechanism of apoptosis in drug resistance of leukemia with relation to DNA topoisomerase and telomerase activity. |
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| Keywords: | DNA topoisomerase telomerase leukemia multi-drug resistance |
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