PAF antagonist ginkgolide B reduces postischemic neuronal damage in rat brain hippocampus |
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| Authors: | H Oberpichler D Sauer C Rossberg H D Mennel J Krieglstein |
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| Affiliation: | Institut für Pharmakologie und Toxikologie, Marburg, F.R.G. |
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| Abstract: | We investigated the effect of the known antagonist of platelet-activating factor (PAF), ginkgolide B, on postischemic neuronal damage in the rat. Neuronal necroses were evaluated in the hippocampus 7 days after a 10-min forebrain ischemia. Preischemic application of ginkgolide B (50 mg/kg p.o.) significantly reduced neuronal damage. It is suggested that the antagonism of PAF is responsible for this beneficial effect of ginkgolide B. |
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