| Abstract: | Objective To investigate effect of p27^kipl and cyclinE proteins on the genesis and progression ofhuman pancreatic cancer. Methods The expression of p27^kipl and cyclinE in tumor tissue and adjacent tissue of 32 patients with pancreatic cancer were detected by SP immunohistochemical technique. Results p27^kipl protein postitive-expression rate in tumor tissue of pancreatic cancer was 56%,which was lower than that in adjacent pancreatic tissue(P&;lt;0.05),p27^kipl protein positive-expression correlated significantly with tumor cell differentiation and lymphy node metastasis (P&;lt;0.05);cyclinE positive-expression rate was 69%, which was higher than that in adjacent pancreatic tissue(P&;lt;0.05),cyclinE positive-expression also correlated significantly with tumor cell differentiation and lymphy node metastasis (P&;lt;0.05).Conclusions p27^kipl and cyclinE proteins may play an important role in genesis and progression of pancreatic cancer. |
