Profile of Cytokines in Synovial Fluid Specimens from Patients with Arthritis. Interleukin 8 (IL-8) and IL-6 Correlate with Inflammatory Arthritides |
| |
| Authors: | Daniel G Remick Laura E Deforge James F Sullivan Henry J Showell |
| |
| Institution: |
a Department of Pathology, The University of Michigan Medical School, Ann Arbor, Michigan
b Associate Clinical Professor of Internal Medicine, Department of Internal Medicine, Yale University School of Medicine,
c Department of Immunology and Infectious Diseases, Central Research Division, Pfizer Inc., Groton, Connecticut |
| |
| Abstract: | The synovial fluid aspirated from patients with symptomatic arthritis was analyzed for the presence of tumor necrosis factor (TNF), interleukin 6 (IL-6) and interleukin 8 (IL-8). All three cytokines were found in both inflammatory and non-inflammatory arthritides: IL-8 levels ranged from less than 20 to 38,990 pg/ml, IL-6 from less than 10 to 72,300 pg/ml and TNF from less than 4 to 61 pg/ml. No inhibitors of cytokine activity were found. IL-8 and IL-6 were present in significantly higher levels in patients with inflammatory arthritis compared to patients with osteoarthritis, and there was significant correlation between the IL-6 and IL-8 levels. These findings document the presence of multiple cytokines in the synovial fluid specimens of patients with arthritis, and demonstrate that higher cytokine levels accompany inflammatory arthritis. |
| |
| Keywords: | |
| 本文献已被 InformaWorld 等数据库收录！ |
|
