老年血管性痴呆与脑血管病患者血液流变学指标的比较

目的 :探讨老年血管性痴呆 ( VD)、脑血管疾病的发病与血液流变性的关系。方法 :观察老年血管性痴呆 ( VD)患者 45例、脑血管病患者 3 5例的血液流变性状况 ,对其结果比较并进行统计学分析 ,同时 ,对 VD不同智力障碍程度的血液流变性结果比较分析。结果 :血管性痴呆及其不同程度的级别与脑血管对照组比较 ,全血粘度值在高切值 ( 15 0 s- 1 )明显高于脑血管病组 ( P均 <0 .0 5 ) ;血浆粘度值又明显低于脑血管病组 ( P<0 .0 5～ 0 .0 1) ;VD患者红细胞最大变形指数显著低于脑血管病组 ( P<0 .0 5 )。结论 :血液流变性变化对于老年血管性痴呆的诊治不失为有用的临床参考指标 ,红细胞的老年性改变参与了老年血管性痴呆的发生。

Comparable Research on Hemorheology of Gerontal Vascular Dementia and Cerebrovascular Diseases

Objective: To find the relativity of vascular dementia, morbidity of cerebrovascular diseases and hemorheology. Method: Hemorheology in 45 cases of gerontal vascular dementia and 35 cases of cerebrovascular diseases was observed. The results was compared and analyzed with statistical method. At the same time, the hemorheology results was compared and analyzed of different degree of dysnoseia in vascular dementia patients. Result: In the group of vascular dementia, blood viscosity at high shear rate(150 s -1 ) is obviously higher than cerebrovascular disease group( P < 0.05 ). Plasmic viscosity is markedly lower than the group of cerebrovascular diseases( P < 0.05 ～ 0.01 ). The group of vascular dementia is markedly lower than cerebrovascluar disease group in highest deformation parameter of RBC( P < 0.05 ). Conclusion: The changes of blood viscosity in diagnosing and treating vascular dementia can be a useful clinic reference standard. Geriatric changes of RBC are related to geriatric vascular dementia.