| DNA双链修复相关基因NBS1的分子改变与肿瘤发生 |
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| 引用本文： | 王岩,黄坚. DNA双链修复相关基因NBS1的分子改变与肿瘤发生[J]. 陕西肿瘤医学, 2013, 0(9): 2127-2130 |
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| 作者姓名： | 王岩 黄坚 |
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| 作者单位： | 首都医科大学附属北京友谊医院肝病中心,北京100050 |
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| 摘 要： | NBS1基因是一种重要的DNA双链修复相关基因,对维持基因组稳定性及防止细胞癌变具有非常关键的作用.近年研究发现NBS1基因的突变、SNP基因型以及NBS1蛋白表达改变与肿瘤的发生风险和预后有关,本文对此作一综述.
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| 关 键 词： | NBS1基因 NBS1表达 基因突变 SNP 肿瘤 |
Molecular alteration of NBS1 gene and tumorgenesis |
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| Wang YanLiver Research Center,Beijing Friendship Hospital,Capital Medical University,Beijing,China Huang Jian. Molecular alteration of NBS1 gene and tumorgenesis[J]. Shaanxi Oncology Medicine, 2013, 0(9): 2127-2130 |
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| Authors: | Wang YanLiver Research Center Beijing Friendship Hospital Capital Medical University Beijing China Huang Jian |
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| Affiliation: | Wang Yan(Liver Research Center,Beijing Friendship Hospital, Capital Medical University,Beijing 100050, China) Huang Jian(Liver Research Center,Beijing Friendship Hospital, Capital Medical University,Beijing 100050, China) |
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| Abstract: | NBS1 is important for repairing DNA double-strand breaks,remaining genomic stability and preventing cell carcinogenesis.In recent years,researchers have found that NBS1 gene mutation,SNP genotype and protein expression are related with risk and prognosis of tumors,which is reviewed in this paper. |
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| Keywords: | NBS1 expression NBS1 gene matatuion tumor |
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