强直性脊柱炎患者性功能及抑郁状态的研究

目的通过问卷调查的方法,探讨强直性脊柱炎(AS)患者性功能及抑郁状态,并讨论勃起功能障碍(ED)与疾病活动的相关性。方法使用勃起功能国际指数(IIEF)、贝克抑郁量表(BDI),对AS患者性功能及抑郁状况进行评估,并分析AS患者ED与患者年龄、病程、晨僵时间、Bath强直性脊柱炎活动指标(BASDAI)、C反应蛋白(CRP)、红细胞沉降率(ESR)以及抑郁状态的相关性。结果①与健康对照组比较,男性AS患者的勃起功能、性交满意度、性高潮以及总满意度评分均较低,差异有统计学意义(P值分别为0.01,0.00,0.00,0.00),其性欲评分差异无统计学意义(P=0.74)。AS患者抑郁的平均积分较高(4±4),差异有统计学意义(P=0.00)。②经Logistic回归分析,除年龄、晨僵时间外,AS患者的其他临床症状和实验室指标均与ED无相关性。结论 AS患者与健康人群相比,可能伴有性功能减低及抑郁状态。AS患者ED的发生与患者年龄、晨僵呈正相关。

Sexual function and depression state in patients with ankylosing spondylitis

Objective To study the sexual function and depression in patients with ankylosing spondylitis （AS） by questionnaire survey and to analyse the correlation between erectile dysfunction （ED） and patients＇ disease activity. Methods International index of erectile function （IIEF） questionnaire and the Beck depression inventory （BDI） were employed to respectively assess the patients＇ sexual function and depression state. The correlations between ED and patients＇ age, disease duration, duration of morning stiffness, Bath ankylosing spondylitis disease activity index （BAS- DAI）, Serum C-reactive protein （CRP）, erythrocyte sedimentation rate （ESR） as well as depression state were analyzed. Results ① Compared with the healthy control group, male patients with AS had significantly lower scores in erectile function, intercourse satisfaction, orgasmic function, and overall satisfaction （P value were 0.01, 0.00, 0.00, 0.00 respectively）. However, there was no significant difference in sexual desire （P=0.74）. The average BDI score of patients with AS was higher （4±4）, which was statistically different from healthy controls （P=-0.00）. ②Logistic regression analysis showed that, except for age and duration of morning stiffness, other clinical symptoms and laboratory indicators showed no correlation with ED. Conclusion Compared with the healthy control group, AS patients are more likely to have sexual dysfunction and depression. Occurrences of ED in AS patients are positively correlated with age and duration of morning stiffness.