Differences in the potentiation of carbon tetrachloride in rats by ethanol and isopropanol pretreatment |
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| Authors: | G J Traiger G L Plaa |
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| Affiliation: | 1. College of Mechanical and Electronic Engineering, Northwest A&F University, Yangling 712100, China;2. School of Automobile, Chang’an University, Xi’an 710064, China;3. Department of Mechanical Science and Engineering, University of Illinois at Urbana Champaign, IL 61801, USA;1. School of Chemistry and Environmental Engineering, Yancheng Teachers University, Yancheng, Jiangsu 224002, People’s Republic of China;2. Department of Chemistry, Jouybar Branch, Islamic Azad University, 4776186131 Jouybar, Iran;3. College of Chemistry & Chemical Engineering, YangZhou University, YangZhou, Jiangsu 225002, People’s Republic of China;1. Gazi University, Technical Sciences Vocational High School, Ankara, Turkey;2. Burdur Mehmet Akif Ersoy University, Technical Sciences Vocational High School, Burdur, Turkey;3. Gazi University, Faculty of Technology, Department of Automotive Engineering, Ankara, Turkey;1. School of Environmental Science and Engineering, Tianjin University, 300072 Tianjin, China;2. Tianjin Key Lab of Biomass/Wastes Utilization, Tianjin University, 300072 Tianjin, China;3. North China Pharmaceutical Group New Drug R&D Co., Ltd., 050091 Hebei, China;4. School of Earth System Science, Tianjin University, 300072 Tianjin, China;5. State Key Laboratory of Engines, Tianjin University, 300072 Tianjin, China |
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| Abstract: | A series of aliphatic alcohols were tested for ability to potentiate the toxicity of carbon tetrachloride (CCl4) in mice. The alcohols were given orally at 50% of the LD50 value, 20 hr prior to an ip injection of 0.0075 mg/kg of CCl4. Using serum glutamicpyruvic transaminase (SGPT) activity to assess the degree of hepatotoxicity, methanol, ethanol, and isopropanol displayed potentiating ability and produced elevated serum enzyme activities. The most marked potentiation was produced by isopropanol. Administration of the alcohols or CCl4 alone did not result in similar changes in SGPT values. In an attempt to characterize the apparent differences in potentiating ability, liver triglyceride concentrations, liver glucose-6-phosphatase activity, and SGPT activity were measured in the rat after giving ethanol or isopropanol 3–48 hr before 0.1 ml/kg of CCl4. Isopropanol (2.5 ml/kg) was found to produce a more marked change than ethanol (5.0 ml/kg) in all 3 parameters studied. In addition, in fed animals, isopropanol plus CCl4 was singularly capable of producing hyperbilirubinemia, an effect not elicited by ethanol plus CCl4, or CCl4 alone at a 10-fold increase in dosage. |
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