A novel method for evaluating natural and vaccine induced serological responses to Bordetella pertussis antigens |
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| Authors: | G.A.M. Berbers M.S.E. van de Wetering P.G.M. van Gageldonk J.F.P. Schellekens F.G.A. Versteegh P.F.M. Teunis |
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| Affiliation: | 1. Center for Infectious Disease Control, National Institute of Public Health and the Environment, Antonie van Leeuwenhoeklaan 9, 3721 MA Bilthoven, The Netherlands;2. Emory University, Rollins School of Public Health, Grace Crum Rollins Building, 1518 Clifton Road, Atlanta, GA 30322, USA;3. Laboratorium voor Infectieziekten, Van Swietenlaan 2, 9728 NZ Groningen, The Netherlands;4. Groene Hart Ziekenhuis, Graaf Florisweg 77-79, 2805 AH Gouda, The Netherlands |
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| Abstract: | We studied the time course of serum IgG antibodies against 3 different pertussis vaccine antigens: PT (pertussis toxin), FHA (filamentous hemagglutinin), Prn (pertactin) in sera from individuals vaccinated with four different pertussis vaccines at 4 years of age: (N = 44, 44, 23 and 23, respectively,) and compared the responses to/after natural infection with Bordetella pertussis (N = 44, age 1–8 years). |
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| Keywords: | Pertussis Whole cell Acellular Vaccine Mixed model Serology Infection |
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