Antigen sparing with adjuvanted inactivated polio vaccine based on Sabin strains |
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| Authors: | Janny Westdijk Patrick Koedam Mario Barro Benjamin P. Steil Nicolas Collin Thomas S. Vedvick Wilfried A.M. Bakker Peter van der Ley Gideon Kersten |
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| Affiliation: | 1. Institute for Translational Vaccinology, Antonie van Leeuwenhoeklaan 9, 3720 AL Bilthoven, The Netherlands;2. Bilthoven Biologicals, Department of Quality Control, Antonie van Leeuwenhoeklaan 9-13, 3720 AL Bilthoven, The Netherlands;3. Global Vaccines Inc., Research Triangle Park, NC 27709, USA;4. Vaccine Formulation Laboratory, Department of Biochemistry, University of Lausanne, 1066 Epalinges, Switzerland;5. Infectious Disease Research Institute, Seattle, WA 98104, USA;6. Division of Drug Technology, Leiden Academic Center for Drug Research, Leiden University, PO Box 9502, 2300 RA Leiden , The Netherlands;g The United States Biomedical Advanced Research and Development Authority, US Department of Health and Human Services, Washington, DC 20201, USA |
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| Abstract: | Six different adjuvants, each in combination with inactivated polio vaccine (IPV) produced with attenuated Sabin strains (sIPV), were evaluated for their ability to enhance virus neutralizing antibody titres (VNTs) in the rat potency model. The increase of VNTs was on average 3-, 15-, 24-fold with adjuvants after one immunization (serotypes 1, 2, and 3, respectively). Also after a boost immunization the VNTs of adjuvanted sIPV were on average another 7–20–27 times higher than after two inoculations of sIPV without adjuvant. The results indicate that it is feasible to increase the potency of inactivated polio vaccines by using adjuvants. |
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| Keywords: | Sabin IPV Oil-in water PagL AlOH3 Replicon particles MPL |
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