| 黄芩素纳米混悬液的生物利用度研究 |
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| 引用本文： | 高缘,江鲲,李莉,席一峰. 黄芩素纳米混悬液的生物利用度研究[J]. 中国药科大学学报, 2011, 42(4): 314-318 |
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| 作者姓名： | 高缘 江鲲 李莉 席一峰 |
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| 作者单位： | 中国药科大学中药制剂教研室;中国药科大学中药制剂教研室;南京医科大学第二附属医院;中国药科大学中药制剂教研室 |
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| 基金项目： | 国家“重大新药创制”科技重大专项资助项目(No.2009ZX09310-004)；中央高校基本科研业务费专项资金资助（No.JKQ2009028） |
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| 摘 要： | 采用反溶剂重结晶结合高压均质法制备黄芩素纳米混悬液,并对其在大鼠体内的生物利用度进行研究。对大鼠分别灌胃给予等剂量黄芩素原料和黄芩素纳米混悬液，采用HPLC法测定活性代谢产物黄芩苷在大鼠体内的血药浓度，利用DAS 2.0软件计算药代动力学参数。结果表明，灌胃给予等剂量黄芩素原料和黄芩素纳米混悬液(121 mg/kg)后，大鼠血浆中黄芩苷的血药浓度-时间曲线均呈现双峰现象，cmax分别为7.18和11.12 μg/mL，tmax分别为1.67和0.92 h，AUC0-24 h分别为71.40和118.63μg·h/mL。以黄芩素原料做参比，黄芩素纳米混悬液经口给药后的相对生物利用度为166.1%。黄芩素纳米混悬液可显著提高黄芩素口服给药的生物利用度。
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| 关 键 词： | 黄芩素；黄芩苷；纳米混悬液；生物利用度；药代动力学 |
Bioavailability enhancement of baicalein by nanosuspension |
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| GAO Yuan,JIANG Kun,LI Li and XI Yi-feng. Bioavailability enhancement of baicalein by nanosuspension[J]. Journal of China Pharmaceutical University, 2011, 42(4): 314-318 |
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| Authors: | GAO Yuan JIANG Kun LI Li XI Yi-feng |
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| Affiliation: | GAO Yuan1,JIANG Kun1,LI Li2,XI Yi-feng1 1 Department of Traditional Chinese Medicine Pharmaceutics,China Pharmaceutical University,Nanjing 210009,2 No.2 Affiliated Hospital of Nanjing Medical University,Nanjing 210011,China |
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| Abstract: | Baicalein nanosuspension was prepared by antisolvent recrystalization method combined with subse-quent homogenization.The oral bioavailability of baicalein nanosuspension in rats was also studied.The concen-tration of baicalin in rat plasma was determined by HPLC method.The pharmacokinetic parameters were calculat-ed by DAS 2.0 software.It was found that the plasma drug concentration-time curves of baicalein all showed two peaks after oral administration.The cmax,tmaxand AUC0-24 h of the raw baicalein and b... |
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| Keywords: | baicalein baicalin nanosuspension bioavailability pharmacokinetics |
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