| 丹参注射液水溶性成分含量变化对大鼠体内高半胱氨酸代谢的影响 |
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| 引用本文： | 程昱,何华,陈渊成,黄黎华,司倩,柳晓泉.丹参注射液水溶性成分含量变化对大鼠体内高半胱氨酸代谢的影响[J].中国药科大学学报,2011,42(3):255-261. |
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| 作者姓名： | 程昱 何华 陈渊成 黄黎华 司倩 柳晓泉 |
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| 作者单位： | 中国药科大学药物代谢动力学研究中心;中国药科大学药物代谢动力学研究中心;复旦大学附属华山医院抗生素研究所;中国药科大学药物代谢动力学研究中心;中国药科大学药物代谢动力学研究中心;中国药科大学药物代谢动力学研究中心 |
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| 基金项目： | 国家自然科学基金资助项目 (No.30772609) |
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| 摘 要： | 考察丹参注射液中主要水溶性成分丹参素(DSS),原儿茶醛(Pa1),丹酚酸A(SalA)和丹酚酸B(SalB)含量变化对大鼠血浆中高半胱氨酸(Hcy)代谢的影响.大鼠随机分为急性心肌缺血模型组、丹参注射液组和4个成分外加组,后者在丹参注射液基础上依次外加DSS、Pal、SalA和SalB至原有含量的3倍、2倍、10倍和...
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| 关 键 词： | 丹参注射液 药效学 相互作用 高半胱氨酸 还原型谷胱甘肽 贡献率 急性心肌缺血 |
Effects of content variation of water-soluble components in Dansheninjection on homocysteine metabolism in rats |
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| CHENG Yu,HE Hu,CHEN Yuan-cheng,HUANG Li-hu,SI Qian and LIU Xiao-quan.Effects of content variation of water-soluble components in Dansheninjection on homocysteine metabolism in rats[J].Journal of China Pharmaceutical University,2011,42(3):255-261. |
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| Authors: | CHENG Yu HE Hu CHEN Yuan-cheng HUANG Li-hu SI Qian and LIU Xiao-quan |
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| Institution: | CHENG Yu1,HE Hua1,CHEN Yuan-cheng2,HUANG Li-hua1,SI Qian1,LIU Xiao-quan1 1Center of Drug Metabolism and Pharmacokinetics,China Pharmaceutical University,Nanjing 210009,2Institute of Antibiotics,Huashan Hospital,Fudan University,Shanghai 200040,China |
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| Abstract: | This study was to investigate the effects of content variation of major water-soluble components in Danshen injection on homocysteine(Hcy) metabolism in rats.Acute myocardial infarction(AMI) rats were induced by coronary artery ligation,and then randomly divided into model control,Danshen injection group,and Danshen injection with the addition of danshensu(DSS),protocatechuic aldehyde(Pal),salvianolic A(SalA) or salvianolic B(SalB),respectively.Based on plasma concentrations of Hcy and glutathione(GSH),a ne... |
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| Keywords: | Dansheninjection pharmacodynamic interaction homocysteine reduced glutathione contribution acute myocardial infarction |
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