| 天钩降压胶囊对自发性高血压大鼠血压的影响 |
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| 引用本文： | 李玉洁,杨庆,翁小刚,陈颖,李丹,邹丽娟,朱晓新.天钩降压胶囊对自发性高血压大鼠血压的影响[J].中国中药杂志,2011,36(23):3353-3357. |
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| 作者姓名： | 李玉洁 杨庆 翁小刚 陈颖 李丹 邹丽娟 朱晓新 |
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| 作者单位： | 中国中医科学院中药研究所,北京,100700 |
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| 基金项目： | 国家"重大新药创制"科技重大专项(2009ZX09103-403) |
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| 摘 要： | 目的:观察天钩降压胶囊的药效作用.方法:13～14周龄SPF级SHR大鼠,按血压及体重随机分为模型对照组、天钩降压胶囊低、中、高剂量组(给药剂量按生药计分别为5.4,10.8,21.6 g·kg-1)、阳性对照药卡托普利组(0.03 g·kg-1).每天灌胃给药1次,持续4周.监测清醒动物血压、心率、心室指数、尿量及血液中肾素( PRA)、血管紧张素Ⅱ( AngⅡ)和醛固酮(ALD)含量.结果:天钩降压胶囊低、中、高剂量组能显著降低SHR大鼠收缩压、舒张压和平均动脉压(P ＜0.05或P＜0.01),低、中剂量组能减慢SHR大鼠心率(P＜0.01),低剂量组可有效抑制左心室指数(P＜0.05).天钩降压胶囊对SHR大鼠RRAS活性和排尿量无明显影响.结论:天钩降压胶囊可显著降低SHR大鼠血压,其作用与减慢心率、抑制心室指数有关,与RAAS系统及利尿作用无关.
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| 关 键 词： | 天钩降压胶囊 自发性高血压大鼠 血压 RAAS系统 尿量 |
| 收稿时间： | 8/2/2011 12:00:00 AM |
Effects of Tiangou Jiangya capsule on blood pressure in spontaneous hypertensive rat |
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| LI Yujie,YANG Qing,WENG Xiaogang,CHEN Ying,LI Dan,ZOU Lijuan and ZHU Xiaoxin.Effects of Tiangou Jiangya capsule on blood pressure in spontaneous hypertensive rat[J].China Journal of Chinese Materia Medica,2011,36(23):3353-3357. |
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| Authors: | LI Yujie YANG Qing WENG Xiaogang CHEN Ying LI Dan ZOU Lijuan and ZHU Xiaoxin |
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| Institution: | Institute of Chinese Materia Medica, China Academy of Traditional Chinese Medicine Sciences, Beijing 100700, China;Institute of Chinese Materia Medica, China Academy of Traditional Chinese Medicine Sciences, Beijing 100700, China;Institute of Chinese Materia Medica, China Academy of Traditional Chinese Medicine Sciences, Beijing 100700, China;Institute of Chinese Materia Medica, China Academy of Traditional Chinese Medicine Sciences, Beijing 100700, China;Institute of Chinese Materia Medica, China Academy of Traditional Chinese Medicine Sciences, Beijing 100700, China;Institute of Chinese Materia Medica, China Academy of Traditional Chinese Medicine Sciences, Beijing 100700, China;Institute of Chinese Materia Medica, China Academy of Traditional Chinese Medicine Sciences, Beijing 100700, China |
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| Abstract: | |
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| Keywords: | Tiangou Jiangya capsule spontaneously hypertensive rats blood pressure renin-angiotensin-aldosterone system urinary output |
| 本文献已被 CNKI 万方数据 PubMed 等数据库收录！ |
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