低钾性周期性麻痹120例临床分析

目的探讨低钾性周期性麻痹的临床特点。方法回顾性分析自1999~2007年收治的120例低钾性周期性麻痹病人的临床资料。结果大部分病例(65.0%)有较明显诱因;多在夜间睡眠、清晨醒后起病占83.3%;均为急性起病以四肢瘫痪为主,近端重于远端,下肢重于上肢,腱反射具有多样性;120例患者治疗前血清钾均较正常水平低。部分患者(21.6%)合并甲亢,其甲状腺功能测定均显示平均FT3、FT4升高,TSH降低。结论低钾性周期性麻痹有其临床特点,早期诊断及时补钾治疗与预后密切相关;合并甲亢者治疗甲亢同时补钾。

CLINICAL ANALYSIS OF 120 PATIENTS WITH HYPOKALEMIC PERIODIC PARALYSIS

Objective To explore the clinic feature of hypokalemic periodic paralysis. Methods Retrospectively analyze clinical data of 120 patients with hypokalemic periodic paralysis in hospital from 1999 to 2007. Results 65.0%patients had obvious inducement; 83.3% onset during nighttime or early morning; they all onset urgently and most with tetraplegia, proximal end outweighed distal end, the lower limbs outweighed the upper limbs and tendon reflex was diversity; serum potassium of 120 patients were lower than common level prior treatment. 21.6% patients complicated with hyperthyrosis, their thyroid function examination showed that average FT3 and FT4 were step up while TSH was step down. Conclusion Hypokalemic periodic paralysis had its clinic feature, early diagnosis and replenishment of potassium in time had close correlation with prognosis; that complicated hyperthyrosis needed relevant treatment and replenishment of potassium.