葛根异黄酮对AD模型大鼠抗衰老作用研究

目的 研究葛根异黄酮对D-半乳糖致衰老大鼠的抗衰老作用.方法 wistar大鼠68只,随机分为对照组、模型组、药物组低、高剂量组,每组17只.造模成功后,第二天开始灌胃给药,药物低、高剂量组每天分别给予40mg/kg、160 mg/kg葛根异黄酮灌胃,模型组、对照组每天给予80 mg/kg生理盐水灌胃,连续8周后取血液...

A Study on the Anti-aging Effects of Pueraria Isoflavones on AD Model Rats

Objective To investigate the anti-aging effects of Pueraria isoflavones on AD model rats.Methods 68 wistar rats were randomly divided into control group,model group and medication groups with low and high dose averagely.After a successful modeling,began the next day gavage,medication groups with low and high dose were given 40mg/kg and 160mg/kg isoflavones puerarin respectively daily,while model group and control group were given 80mg/kg normal saline daily.After 8 weeks,blood was drawn,and the liver and brain tissue of rats were taken after decapitation to produce 10% of hippocampal tissue so as to measure the enzymatic activity of malondialdehyde（MDA） and superoxide dismutase（SOD）,glutathione peroxidase（GSH-Px）,monoamine oxidase（MAO）.Results The activity of blood,liver,hippocampus SOD and GSH-Px in the model group were significantly decreased,while MDA level increased significantly.Compared with the control group,there was significant difference（P0.01）.Compared with model group,medication groups with low and high dose showed significant improvement in above parameters（P0.05）,and the high-dose group showed better results than low-dose group（P0.01）;after treatment,blood and liver tissue MAO vitality in both low and high dose groups showed no significant changes,but it was significantly lower in the hippocampus（P0.05）.Conclusion Pueraria isoflavones has anti-aging effects in that it can increase the SOD and GSH-Px activity of i blood and liver and lower the MDA activity of blood,liver and brain tissue.