以归脾汤为基础方治疗心脾两虚型失眠症的系统评价

目的 系统评价归脾汤治疗心脾两虚型失眠症的疗效.方法 按Cochrane系统评价方法,计算机检索CBM,CNKI,VIP及万方等数据库,查找应用归脾汤及其加减方治疗失眠症的随机对照试验和半随机对照试验,应用RevMan4.2.7版进行统计分析.结果 共纳入12项研究,1004例患者.Meta分析结果显示比值比（OR） 4.08,95%CI[2.72～6.13].结论 就本次系统评价结果显示,归脾汤及其加减方治疗失眠症有较好疗效,但仍需关键性结局评价指标进行验证,鉴于纳入的研究质量较低,且存在发表性偏倚,上述结论尚需进一步开展大规模、高质量的并且具有中医特色的研究来验证.

A Systematic Review for Efficacy of Jiajian GuiPi Decoction for Insomnia

Objective To evaluate the effectiveness of GuiPi decoction for insomnia. Methods All randomized controlled trials （RCTs）and quasi-RCTs on GuiPi decoction for insomnia were searched in the VIP, CNKI, CBM disc and Wan fang data. The quality of RCTs meeting inclusion criteria was evaluated and the related data were extracted. Meta-analyses were performed with RevMan 4. 2. 7 software. Results A total of 12 trials were included in this study, including 1004 cases. Meta-analyses showed that total effective rate OR =4. 08,95% CI[2.72- 6. 13 ]. Conclusion The present evidence showed that GuiPi decoction for insomnia has a better efficacy but key outcome should be evaluated. For the low quality and potential publication bias of included study, large-scale, the studies of high-quality researches and with TCM features should be performed.