Reactivity of the basilar artery in Krushinsky-Molodkina rats 24 hours after an audiogenic epileptic seizure |
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| Authors: | T P Storozhevykh V G Pinelis V B Koshelev O E Fadyukova |
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| Institution: | (1) Laboratory of Membranology, Institute of Pediatrics, Russian Academy of Medical Sciences, Moscow;(2) Interfaculty Laboratory of Pathophysiology, Moscow State University, Moscow, USSR |
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| Abstract: | Examination of the reactivity exhibited by the basilar artery of the brain in Krushinsky-Molodkina rats before and after an
induced epileptiform seizure accompanied by subarachnoid hemorrhages showed increased contractility of this artery in response
to endothelin-1 and its reduced sensitivity to ATP 24 h after the seizure. Such changes in the reactivity of brain vessels
may contribute to the development of vasospasm and secondary ischemia of the brain after an epileptic seizure.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 121, N
o
2, pp. 131–134, February, 1996
Presented by M. Ya. Studenikin, Member of the Russian Academy of Medical Sciences |
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| Keywords: | epilepsy subarachnoid hemorrhage brain vessels reactivity endothelin |
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