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Mesophase formation during cholesterol gallstone dissolution in human bile: effect of bile acid composition
Authors:C C Su  W I Higuchi  I T Gilmore  R G Danzinger  A F Hofmann
Abstract:Duodenal bile obtained from patients with gallstones who were acutely infused with chenodeoxycholic acid, ursodeoxycholic acid, or cholic acid were examined for the propensity toward the formation of a liquid crystalline mesomorphic phase when cholesterol gallstones were incubated in these bile acids. Bile taken from patients infused with ursodeoxycholic acid was found to be enriched in ursodeoxycholic acid; mesophase formation was detected in these samples but not in bile from patients infused with chenodeoxycholic acid or cholic acid.
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