Breast Cancer during Pregnancy: An Interdisciplinary Approach in Our Institution |
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Authors: | Cristina Pirvulescu Christine Mau Holger Schultz Antje Sperfeld Annette Isbruch Heike Renner-Lützkendorf Sybille Loibl Ulrike Freitag Gabriele Klühs Barbara Fleige Michael Untch |
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Institution: | aDepartment of Gynecology and Obstetrics, Helios Hospital Berlin-Buch, Germany;bGerman Breast Group, Neu-Isenburg, Helios Hospital Berlin-Buch, Germany;cRadiological Department, Helios Hospital Berlin-Buch, Germany;dHematooncological Department, Helios Hospital Berlin-Buch, Germany;ePathological Institute, Helios Hospital Berlin-Buch, Germany |
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Abstract: | BackgroundBreast cancer is the most common cancer diagnosed during pregnancy.Case ReportWe report on a case of a 26-year-old woman who was diagnosed with right-sided breast cancer in her 15th week of gestation. We discussed possible treatment scenarios and the patient opted for neoadjuvant therapy with taxanes and anthracyclines during pregnancy, followed by delivery and then followed by surgery, antibody therapy, and radiotherapy. The patient received neoadjuvant chemotherapy with paclitaxel 80 mg/m2 weekly for 12 cycles, followed by 4 cycles of epirubicin and cyclophosphamide (90/600 mg/m2) every 3 weeks. Complete clinical response was seen after preoperative chemotherapy. After delivery of a healthy child at 40 weeks of gestation, she received breast-conserving surgery and axillary dissection. Anti-HER2 antibody treatment with trastuzumab was started concomitantly with adjuvant radiotherapy. Endocrine treatment with a gonadotropin-releasing hormone (GnRH) analog and tamoxifen for 5 years was planned to be started after radiotherapy.ConclusionTreatment of breast cancer during pregnancy requires an interdisciplinary approach and careful consideration of the patient''s stage of disease, the gestational age, and the preferences of the patient and her family. |
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Keywords: | Pregnancy-associated breast cancer Outcome of pregnancy Neoadjuvant chemotherapy Interdisciplinary care |
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