急性脑梗死患者血栓前状态的特征分析

目的:探讨急性脑梗死患者血栓前状态(PTS)血浆D-二聚体(D-dimer)、纤维蛋白原(FIB)含量和血液流变学指标的变化。方法:用酶联免疫吸附试验(ELISA)法、全自动血凝仪和全自动血液粘度分析仪分别检测120例急性脑梗死患者发病24h内及60例健康对照组血浆D-dimer、FIB和全血粘度(高切、低切)、血浆粘度、红细胞聚集指数。结果:急性脑梗死患者血浆D-二聚体、纤维蛋白原含量和全血粘度(高切、低切)、血浆粘度、红细胞聚集指数明显增高,与健康对照组比较有非常显著的差异(P<0.01)。结论:血浆纤维蛋白原含量和血液流变学指标的测定可以作为脑梗死患者血栓前状态初筛试验,血浆D-dimer测定可作为脑梗死患者血栓前状态特异而敏感的诊断指标。

Characterisitics of the prethrombotic state of acute cerebral infarction

Objective:To explore characteristics of the prethrombotic state of acute cerebral infarction (ACI) by measuring levels of plasma D-dimer, fibrinogen and rheological indices. Methods:Plasma D-dimer, fibrinogen, whole blood viscosity (high and low shear), plasma viscosity, and erythrocyte aggregation index were measured by the method of enzyme linked immunoabsorbant assay (ELISA) , and using full automatic blood coagulation analyzer and full automatic blood viscosity analyzer in 120 ACI within 24 hours of onset subjects and in 60 healthy control subjects. Results: Plasma D-dimer, fibrinogen, whole blood viscosity (high and low shear), plasma viscosity, and erythrocyte aggregation index in ACI subjects markedly increased as compared with the healthy control subjects with statistically significant difference (P<0.01). Conclusion: Determination of levels of plasma fibrinogeand blood rheological indices may be utilized as preliminary screening test for the prethombotic state of ACI. and plasma D-dimer may be used as sensitive and specific diagnostic index for it.