硝酸酯类药物口服与静脉联合应用疗效及合理性评价与分析

目的：对某医院硝酸酯类药物口服与静脉联合应用疗效及合理性评价与分析，为临床应用提供参考。方法采用样本分析方法，收集2015年3月至2016年3月某医院心血管内科使用硝酸酯类药物的300份病历，统计分析使用剂型及联合用药对疗效和不良反应（ ADR）的影响。结果联合应用与单独应用某一剂型相比总有效率并无显著性差异（P＞0．05），联合应用口服加静滴的患者出现ADR时间早、ADR发生率高，以头痛症状为主。结论口服联合静脉给予硝酸酯类药物治疗冠心病心绞痛疾病时，较单独给予一种剂型时疗效并无明显增强，但不良反应出现加快，耐药性产生加快。

Comprehensive evaluaion and analysis of isosorbide dinitrate,by oral,intra-venous drip and combined use

Objective To comprehensive evaluaion and analysis the rationalisation of isosorbide dinitrate ,by oral,in-travenous drip and combined use .To provide a reference for clinical application of atorvastatin .Methods 300 pa-tients using nitric acid lipid drug in our hospital were selected as research objects from March 2015 to March 2016. The influence of the dosage and the combined medication to ADR were analyzed .Results There was no significant difference between the joint application and a separate application (P>0.05),and durg combination was one of the risk factors lead to ADR .Conclusion The oral joint vein of nitrate for treatment of coronary heart disease and angi-na disease has no obvious advantage as compared with a dosage form alone ,but lead to adverse reaction increased and resistance speed up .