Pycnogenol accelerates wound healing and reduces scar formation |
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Authors: | Blazsó G Gábor M Schönlau F Rohdewald P |
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Affiliation: | Department of Pharmacodynamics and Biopharmacy, Szent-Gy?rgyi Albert Medical and Pharmaceutical Center, University of Szeged, Hungary. blazso@pharma.szote.uszeged.hu |
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Abstract: | Pycnogenol was applied topically to experimental wounds inflicted on healthy rats by means of a branding iron. The wound-healing time was taken as the number of days required for 50% of the scabs to separate spontaneously from the animals. Application of a gel formulation containing 1% Pycnogenol significantly shortened the wound healing time, by 1.6 days compared with the group treated with gel only (15.4 days). The application of 2% Pycnogenol decreased the healing time by almost 3 days, while 5% Pycnogenol further accelerated the wound-healing process. In parallel, Pycnogenol gels reduced the diameter of the scars remaining following complete scab loss in a concentration-dependent manner. In conclusion, Pycnogenol is a potent active ingredient for the treatment of minor injuries. |
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Keywords: | Pycnogenol® wounds scars |
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