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Repression and reactivation of lithium efflux from erythrocytes. |
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| Authors: | P J Goodnick H L Meltzer D L Dunner R R Fieve |
| Affiliation: | 1. Paul J. Goodnick, M.D., was Resident in Psychiatry, New York State Psychiatric Institute, USA;2. Herbert L. Meltzer, Ph.D., is Research Scientist (Neurochemistry), New York State Psychiatric Institute, USA;3. David L. Dunner, M.D., was formerly at the New York State Psychiatric Institute, USA;4. Ronald F. Fieve, M.D., is Chief of Research, Lithium Clinic, New York State Psychiatric Institute, and Professor of Psychiatry, Columbia University School of Medicine, USA |
| Abstract: | Efflux of lithium from human erythrocytes was studied in patients before, during, and after discontinuation of administration of lithium carbonate. Onset of lithium-induced repression of efflux took approximately 10 days and was significantly shorter in patients who had had lithium therapy previously. Reactivation took a longer period of time--approximately 2 week--and was found to be related to duration of lithium therapy. Theoretical pathways of lithium flow through membranes are discussed. |
| Keywords: | Lithium pump membrane transport lithium efflux lithium carbonate |
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